Biliary Stent Clogging Solved by Nanotechnology? In Vitro Study of Inorganic-Organic Sol-Gel Coatings for Teflon Stents
| Autor: | Klaus Siebert, Andreas Block, Stefan Seewald, Nib Soehendra, Uwe Seitz, Ann–Christina Schaefer, Holger Wulff, Andreas de Weerth, Frank Thonke, Uwe Wienhold, Sabine Bohnacker |
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| Rok vydání: | 2007 |
| Předmět: |
Materials science
Scanning electron microscope medicine.medical_treatment Nanotechnology In Vitro Techniques engineering.material Clogging chemistry.chemical_compound Coated Materials Biocompatible Coating Materials Testing Escherichia coli medicine Bile Humans Biliary Tract Polytetrafluoroethylene Sol-gel Silanes Hepatology Gastroenterology Stent Equipment Design chemistry Biliary tract Microscopy Electron Scanning engineering Epoxy Compounds Stents Gels Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Gastroenterology. 133:65-71 |
| ISSN: | 0016-5085 |
| DOI: | 10.1053/j.gastro.2007.04.006 |
| Popis: | Background & Aims: The major drawback of plastic stents for biliary drainage is the occlusion by sludge. Sludge is accrued because the stent surface allows for the adherence of proteins, glycoproteins, or bacteria and the bile flow is insufficient to clean the surface. In this study, experience from nanotechnology to achieve a clean surface by improved soil-release characteristics is used to optimize biliary stent surface. The aim of this study was to examine sludge accumulation in relation to surface characteristics designed by nanotechnology. Methods: A variety of inorganic-organic sol-gel-coated stents were incubated in sterilized human bile and enzyme-active Escherichia coli for 35 days. Materials were Teflon (DuPont, Wilmington, DE) coated with hydrophobic Clearcoat (NTC, Tholey, Germany), Teflon with sol-gel coating synthesized of organic epoxides of 190 g/mol or 500 g/mol, and propylaminosilane without or with fluorsilanes for increased hydrophobicity. Scanning electron microscopy and semiquantitative analysis, blinded to the type of coating, were used to determine the amount of sludge accumulated on the surface. Results: Sludge deposition was reduced on the designed surfaces as compared with uncoated Teflon and Clearcoat. The performance of high molecular (500 g/mol) was superior to that of low molecular (190 g/mol) epoxide ligand. However, increasing hydrophobicity by adding fluoraminosilanes resulted in increased adherence of sludge. Less than a micrometer-thin sol-gel coating is inexpensive because very little coating material is required. This is the first published data comparing systematically modified surfaces of biliary stents using nanotechnology. Conclusions: Optimized soil release by sol-gel nanocoating of plastic stents may prevent biliary plastic stents from clogging. |
| Databáze: | OpenAIRE |
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