Strategy of integrated evaluation on treatment of traditional Chinese medicine as ‘interaction of system to system’ and establishment of novel fuzzy target contribution recognition with herb-pairs, a case study on Astragali Radix-Fructus Corni
| Autor: | Feng-xian Qiao, Sicong Tu, Ke Pei, Kunming Qin, Hao Cai, Yu Duan, Xinwei Cheng, Zhengwei Zhang, Baochang Cai, Kai-Lei Fan |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Evaluation system NF-E2-Related Factor 2 Computer science Treatment outcome Traditional Chinese medicine Computational biology 030204 cardiovascular system & hematology Pharmacology Biochemistry Fuzzy logic Mice 03 medical and health sciences Cornus 0302 clinical medicine Endocrinology Animals Humans Diabetic Nephropathies Radix Medicine Chinese Traditional Molecular Biology Astragalus propinquus Rats Treatment Outcome 030104 developmental biology Molecular mechanism Drugs Chinese Herbal Signal Transduction |
| Zdroj: | Molecular and Cellular Endocrinology. 434:219-237 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2016.07.006 |
| Popis: | To date, in the struggle against diseases and the development of TCM, what we lack is wisdom rather than knowledge. Studies on pharmacology of traditional Chinese medicine are facing critical challenges on how to select the proper parameters or targets to represent the pharmacological evaluation system. With seven steps of optimized modules established by ourselves, we can re-evaluate TCM in a panorama view with a proper pharmacological evaluation system. In this article, with the treatment of TCM as 'interaction of system to system', a novel and generally applicable approach called fuzzy target contribution recognition was established and agents from Astragali Radix-Fructus Corni in resisting diabetic nephropathy were successfully discovered for the first time. CG6, a promising agent from this herb-pair on the treatment of diabetic nephropathy, was finally acquired and its possible molecular mechanism was explored through a nuclear factor erythroid 2-Like 2 (NFE2L2) activation-dependent pathway. |
| Databáze: | OpenAIRE |
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