Skeletal Muscle Dysfunction and Exercise Intolerance in Children Treated with Haematopoietic Stem Cell Transplant-A Pilot Feasibility Study
| Autor: | Greg D. Wells, Sarah L. West, Gillian E White, Tammy Rayner, Jessica E. Caterini, Tal Schechter, Paul C. Nathan |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Health Toxicology and Mutagenesis muscle metabolism lcsh:Medicine Pilot Projects Exercise intolerance haematopoietic stem cell transplant Article Body Mass Index 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Aerobic exercise Humans Adverse effect Child Muscle Skeletal 030304 developmental biology 0303 health sciences medicine.diagnostic_test exercise business.industry lcsh:R Public Health Environmental and Occupational Health Hematopoietic Stem Cell Transplantation Skeletal muscle Magnetic resonance imaging Magnetic Resonance Imaging Peripheral Haematopoiesis medicine.anatomical_structure surgical procedures operative pediatric 030220 oncology & carcinogenesis Case-Control Studies Exercise Test Feasibility Studies exercise tolerance Female Stem cell medicine.symptom business |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 16, Iss 9, p 1608 (2019) Volume 16 Issue 9 |
| ISSN: | 1660-4601 |
| Popis: | Haematopoietic stem cell transplant (HSCT) is an intensive therapy for some pediatric hematological illnesses. Survivors are at risk for adverse effects including exercise intolerance. Peripheral tissue dysfunction may contribute to exercise intolerance therefore, we examined the feasibility of a magnetic resonance spectroscopy (MRS) protocol to evaluate skeletal muscle metabolism in children post-HSCT. We measured demographic characteristics, aerobic exercise capacity (YMCA protocol), and skeletal muscle function in response to exercise (MRS Siemens 3T MRI) in five children post-allogeneic HSCT and five age/body mass index-matched healthy controls (HCs). The mean age (± standard deviation) of the HSCT group and HC group were 11 ± 1.2 and 12.8 ± 2.4 years, respectively. Children post-HSCT had a lower peak aerobic exercise capacity compared to HCs (27.8 ± 3.4 vs. 40.3 ± 8.1 mL kg&minus 1 min&minus 1, respectively p = 0.015). Exercise MRS testing protocols were successfully completed by all HSCT and HC participants however, MRS-derived skeletal muscle metabolism variables were not different between the two groups. In conclusion, the use of exercise protocols in conjunction with MRS to assess peripheral skeletal muscle metabolism was achievable in children post-HSCT. In the future, larger studies should determine if skeletal muscle function is associated with exercise capacity in children post-HSCT. |
| Databáze: | OpenAIRE |
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