Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor
| Autor: | Mark A. Shifman, Kenneth A. Bauer, Elizabeth E. Campbell, James G. Lewis, Robert D. Rosenberg, Salvatore V. Pizzo, Thomas R. Kinney, Nancy W. Stead |
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| Rok vydání: | 1983 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Platelet Aggregation Fibrinopeptide A Antithrombin III Plasma factor chemistry.chemical_compound Plasminogen Activators Von willebrand Internal medicine von Willebrand Factor medicine Coagulation testing Humans Factor VIII Factor VII business.industry Antithrombin Thrombin Factor V Plasminogen General Medicine Thrombophlebitis medicine.disease Blood Coagulation Factors Pedigree Venous thrombosis Endocrinology chemistry Immunology business Plasminogen activator medicine.drug |
| Zdroj: | The American journal of medicine. 74(1) |
| ISSN: | 0002-9343 |
| Popis: | A family is described in which venous thrombosis developed in five members as early as 14 years of age. Routine coagulation studies, plasma antithrombin III, factor V, plasminogen, beta-thromboglobulin, fibrinopeptide A, prothrombin fragment F1+2, and thrombin-antithrombin III complex were all within normal limits. However, defective release of vascular plasminogen activator was observed on several occasions in all five subjects as compared with a control population of 125 persons (0.04 Committee on Thrombolytic Agents [CTA] units/ml plasma as compared with 0.21 CTS units/ml). In addition, levels of factor VII/von Willebrand's factor were significantly elevated above the normal range in this pedigree. |
| Databáze: | OpenAIRE |
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