ε-Caprolactone in micro-chambered ceramic beads--a new carrier for gentamicin
| Autor: | Yvette Draenert, Miriam E Draenert, Reinhard Hickel |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Ceramics
Materials science Knee Joint Biocompatible Materials chemistry.chemical_compound Lactones Drug Discovery medicine Animals Pharmacology (medical) Ceramic Caproates Pharmacology Drug Carriers Sheep General Medicine Staphylococcal Infections Anti-Bacterial Agents Infectious Diseases Oncology chemistry visual_art Drug delivery visual_art.visual_art_medium Gentamicin Female Gentamicins Caprolactone medicine.drug Biomedical engineering |
| Zdroj: | Chemotherapy. 59(4) |
| ISSN: | 1421-9794 |
| Popis: | Purpose: The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. Methods: The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatibility and biodegradation of the materials was investigated in an animal experiment in sheep up to 14 months. As carrier ε-caprolactone, 1:1 mixed with gentamicin, intruded into micro-chambered β-tricalcium-phosphate beads (MCB®) was studied. Results and Discussion: Gentamicin was released in calculable concentrations during the first 30 days. The release from ε-caprolactone was higher than that from polymethylmethacrylate and more predictable. The caprolactone carrier was reabsorbed by osteoclasts. |
| Databáze: | OpenAIRE |
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