Anti-C1q autoantibodies in lupus nephritis
| Autor: | Beniamina Gallelli, Laura Rimoldi, Antonella Radice, Laura Bianchi, Renato Alberto Sinico, Gabriella Moroni |
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| Přispěvatelé: | Sinico, R, Rimoldi, L, Radice, A, Bianchi, L, Gallelli, B, Moroni, G |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Anti-nuclear antibody
Lupus nephritis Reproducibility of Result Enzyme-Linked Immunosorbent Assay Disease urologic and male genital diseases Anti-DNA antibodie Sensitivity and Specificity General Biochemistry Genetics and Molecular Biology History and Philosophy of Science immune system diseases medicine Humans skin and connective tissue diseases C3 Renal flare Multivariate Analysi Autoantibodies Biochemistry Genetics and Molecular Biology (all) biology business.industry General Neuroscience Lupus nephriti Complement C1q Antibody titer Autoantibody Reproducibility of Results Complement C4 Complement C3 medicine.disease Lupus Nephritis Autoantibodie Titer Multivariate Analysis Immunology biology.protein Anti-C1q antibodie Antibody business Anti-SSA/Ro autoantibodies Human |
| Popis: | Anti-C1q antibodies are found in a variety of diseases, in addition to systemic lupus erythematosus (SLE), and in 3-5% of normal individuals. In particular, anti-C1q antibodies are detected at a high titer in 100% of patients with hypocomplementemic urticarial vasculitis and in 30-48% of SLE patients. Their titer correlates with active renal disease with a sensitivity of 44-100% and a specificity of 70-92%. An increase in anti-C1q antibody titer has been suggested to be able to predict renal flares in lupus nephritis so that monitoring anti-C1q might be valuable for the clinical management of SLE patients as a noninvasive biological marker. Recently our group studied 228 patients affected by lupus nephritis and found that the association of anti-C1q, C3, and C4, in a multivariate analysis, provided the best prediction of renal flares, particularly in patients with focal and diffuse proliferative lupus nephritis and in the absence of antiphospholipid antibodies. © 2009 New York Academy of Sciences. |
| Databáze: | OpenAIRE |
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