Interleukin-1 β facilitates afferent sensory transmission in the primary somatosensory cortex of anesthetized rats
| Autor: | Hyung-Cheul Shin, Chungkil Won, Hyoung-Jin Park |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Afferent Pathways
Dose-Response Relationship Drug Sensory processing General Neuroscience medicine.medical_treatment Stimulation Sensory system Somatosensory Cortex Biology Somatosensory system Synaptic Transmission Rats Rats Sprague-Dawley Electrophysiology medicine.anatomical_structure Somatosensory evoked potential Receptive field Cortex (anatomy) medicine Animals Neuroscience Interleukin-1 |
| Zdroj: | Neuroscience Letters. 201:255-258 |
| ISSN: | 0304-3940 |
| Popis: | The effect of topical application of human recombinant interleukin-1 β (IL-1) on afferent sensory transmission to the neurones in the primary somatosensory (SI) cortex was determined in anesthetized rats. Quantitative determination of the effect of IL-1 was made by generating post-stimulus time histograms of unit responses to the stimulation of receptive field. IL-1 (0.01, 0.1, 1.0 U) significantly facilitated afferent sensory transmission in SI cortical neurones ( n = 22). IL-1-induced facilitation fully recovered by 60 min after drug. In control experiments ( n = 10), saline solution containing 0.2% bovine serum albumin, used as a vehicle, did not affect afferent sensory transmission. Our results suggest that IL-1 may be involved in the processing of afferent sensory information in the SI cortex of rats. |
| Databáze: | OpenAIRE |
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