Associations between DNA methylation and telomere length during early life: insight from wild zebra finches (Taeniopygia guttata)
Autor: | Winnie Boner, Aaron W. Schrey, Simon C. Griffith, Elizabeth L. Sheldon, Pat Monaghan, Shirley Raveh, Riccardo Ton |
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Rok vydání: | 2021 |
Předmět: |
0106 biological sciences
Avian clutch size 0303 health sciences biology dNaM Context (language use) biology.organism_classification 010603 evolutionary biology 01 natural sciences Life history theory Telomere 03 medical and health sciences Biomarkers of aging Natural population growth Evolutionary biology DNA methylation Genetics Epigenetics Ecology Evolution Behavior and Systematics Taeniopygia 030304 developmental biology |
ISSN: | 0962-1083 |
Popis: | Telomere length and DNA methylation (DNAm) are two promising biomarkers of biological age. Environmental factors and life history traits are known to affect variation in both these biomarkers, especially during early life, yet surprisingly little is known about their reciprocal association. Here, we present the first study on a natural population to explore how variation in DNAm, growth rate and early-life conditions are associated with telomere length changes during development. We tested these associations by collecting data from wild, nestling zebra finches in the Australian desert. We found that increases in the level of DNAm were negatively correlated with telomere length changes across early life. We also confirm previously documented effects of post hatch growth rate and clutch size on telomere length in a natural ecological context for a species that has been extensively studied in the laboratory. However, we did not detect any effect of ambient temperature during developmental on telomere dynamics. We also found that the absolute telomere length of wild zebra finches, measured using the in-gel TRF method, was similar to that of captive birds. Our findings highlight exciting new opportunities to link and disentangle potential relationships between environmental, epigenetic and telomere length dynamics during early life. |
Databáze: | OpenAIRE |
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