Inflammatory response of Haemophilus influenzae biotype aegyptius causing Brazilian Purpuric Fever
| Autor: | Luciana Maria de Hollanda, Marcelo Lancellotti, Gisele Cristiane Gentile Cury, Rafaella Fabiana Carneiro Pereira |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Haemophilus influenzae biogroup aegyptius
Haemophilus Infections Virulence Factors lcsh:QR1-502 Virulence Neisseria meningitidis medicine.disease_cause Microbiology lcsh:Microbiology Haemophilus influenzae Cell Line Haemophilus medicine Humans Brazilian purpuric fever Cloning Molecular Gene biology Genetic transfer Epithelial Cells biology.organism_classification medicine.disease Virology Recombinant Proteins QR1-502 Medical Microbiology genetic transfer Cytokines Transformation Bacterial Brazil Research Paper |
| Zdroj: | Brazilian Journal of Microbiology, Vol 45, Iss 4, Pp 1449-1454 (2014) Brazilian Journal of Microbiology, Volume: 45, Issue: 4, Pages: 1449-1454, Published: DEC 2014 Brazilian Journal of Microbiology Brazilian Journal of Microbiology v.45 n.4 2014 Sociedade Brasileira de Microbiologia (SBM) instacron:SBM Scopus-Elsevier |
| ISSN: | 1678-4405 |
| Popis: | The Brazilian Purpuric Fever (BPF) is a systemic disease with many clinical features of meningococcal sepsis and is usually preceded by purulent conjunctivitis. The illness is caused by Haemophilus influenza biogroup aegyptius, which was associated exclusively with conjunctivitis. In this work construction of the las gene, hypothetically responsible for this virulence, were fusioned with ermAM cassette in Neisseria meningitidis virulent strains and had its DNA transfer to non BPF H. influenzae strains. The effect of the las transfer was capable to increase the cytokines TNFα and IL10 expression in Hec-1B cells line infected with these transformed mutants (in eight log scale of folding change RNA expression). This is the first molecular study involving the las transfer to search an elucidation of the pathogenic factors by horizontal intergeneric transfer from meningococci to H. influenzae. |
| Databáze: | OpenAIRE |
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