Pro-inflammatory Cytokines Modulate Glial Apolipoprotein E Secretion
| Autor: | Jean-Francois Blain, Rosanne Aleong, Judes Poirier |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Apolipoprotein E
Interleukin-1beta Biology Proinflammatory cytokine Rats Sprague-Dawley Apolipoproteins E Immune system Extracellular medicine Animals Cells Cultured Tumor Necrosis Factor-alpha Interleukin Rats medicine.anatomical_structure Gene Expression Regulation Neurology Cell culture Astrocytes Immunology lipids (amino acids peptides and proteins) Tumor necrosis factor alpha Neurology (clinical) Inflammation Mediators Neuroglia Astrocyte |
| Zdroj: | Current Alzheimer Research. 5:33-37 |
| ISSN: | 1567-2050 |
| Popis: | Alzheimer's disease (AD) is a neurological disorder characterized by plaques and an elevated immune response. Specifically, increased expression of interleukin (IL)-1 and tumour necrosis factor (TNF)-alpha, has been observed in AD cerebrospinal fluid and temporal brain tissue. Both of these immunomodulators were shown to carry genetic variants that increase the risk of developing AD. Studies have also established the apolipoprotein E (apoE) gene to be a risk factor for AD with epsilon4 carriers having been found to show lower levels of brain apoE. In the present study, treatment of primary rat mixed glial cell cultures with IL-1beta induced a significant increase in extracellular apoE protein. In contrast, treatment primary rat astrocyte and mixed glial cell cultures with TNF-alpha significantly reduced extracellular apoE protein levels. These results are consistent with the notion that elevated cytokine expression directly modulates immunosuppression and indirectly apoE-mediated neuronal remodeling. |
| Databáze: | OpenAIRE |
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