Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19
| Autor: | Nathan A. Junod, Christopher C. Stobart, Audrey R. Young, Dia C. Beachboard, Molly K. Roe |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Protease Antagonists & inhibitors Polyproteins Coronavirus disease 2019 (COVID-19) viruses medicine.medical_treatment Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Functional features 030106 microbiology virus diseases RNA-dependent RNA polymerase Biology medicine.disease_cause Virology 03 medical and health sciences 030104 developmental biology medicine Coronavirus |
| Zdroj: | Journal of General Virology |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/jgv.0.001558 |
| Popis: | Coronavirus protease nsp5 (M pro , 3CL pro ) remains a primary target for coronavirus therapeutics due to its indispensable and conserved role in the proteolytic processing of the viral replicase polyproteins. In this review, we discuss the diversity of known coronaviruses, the role of nsp5 in coronavirus biology, and the structure and function of this protease across the diversity of known coronaviruses, and evaluate past and present efforts to develop inhibitors to the nsp5 protease with a particular emphasis on new and mostly unexplored potential targets of inhibition. With the recent emergence of pandemic SARS-CoV-2, this review provides novel and potentially innovative strategies and directions to develop effective therapeutics against the coronavirus protease nsp5. |
| Databáze: | OpenAIRE |
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