Apolipoprotein C-III Strongly Correlates with Activated Factor VII-Anti-Thrombin Complex: An Additional Link between Plasma Lipids and Coagulation
| Autor: | Marcello Baroni, Barry Woodhams, Barbara Lunghi, Filippo Stefanoni, Francesco Bernardi, Jacopo Croce, Domenico Girelli, Federica Tosi, Oliviero Olivieri, Silvia Udali, Nicola Martinelli, Annalisa Castagna |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Apolipoprotein E Male Apolipoprotein B Coronary Artery Disease 030204 cardiovascular system & hematology Coronary artery disease 0302 clinical medicine medicine.diagnostic_test biology Anticoagulant Thrombin Hematology Middle Aged activated factor VII-anti-thrombin complex Lipids Observational Studies as Topic lipids (amino acids peptides and proteins) Female Glomerular Filtration Rate Risk medicine.medical_specialty Genotype medicine.drug_class Socio-culturale Renal function activated factor VII–anti-thrombin complex Factor VIIa activated factor VII–anti-thrombin complex APOC3 gene polymorphism apolipoprotein C-III coagulation plasma lipids Polymorphism Single Nucleotide Antithrombins 03 medical and health sciences Internal medicine plasma lipids medicine Humans coagulation Blood Coagulation Triglycerides Aged Apolipoprotein C-III business.industry APOC3 gene polymorphism medicine.disease 030104 developmental biology Endocrinology biology.protein Lipid profile business Body mass index Genome-Wide Association Study |
| Zdroj: | Thrombosis and haemostasis. 119(2) |
| ISSN: | 2567-689X |
| Popis: | Activated factor VII–anti-thrombin (FVIIa-AT) complex is a potential biomarker of pro-thrombotic diathesis reflecting FVIIa–tissue factor (TF) interaction and has been associated with mortality in patients with coronary artery disease (CAD). Previous data indicated plasma lipids as predictors of FVIIa-AT variability, and plasma lipoproteins as potential stimulators of the coagulation cascade. Our aim was to evaluate the relationships between FVIIa-AT plasma concentration and a broad apolipoprotein profile (including ApoA-I, ApoB, ApoC-III and ApoE). Within the framework of the observational Verona Heart Study, we selected 666 subjects (131 CAD-free and 535 CAD, 75.4% males, mean age: 61.1 ± 10.9 years) not taking anticoagulant drugs and for whom plasma samples were available for both FVIIa-AT assay and a complete lipid profile. Plasma concentration of FVIIa-AT levels significantly and directly correlated with total and high-density lipoprotein cholesterol, triglycerides, ApoA-I, ApoC-III and ApoE levels. ApoC-III showed the strongest correlation (R = 0.235, p = 7.7 × 10−10), confirmed in all the sub-group analyses (males/females and CAD/CAD-free). Only ApoC-III remained associated with FVIIa-AT plasma concentration, even after adjustment for sex, age, CAD diagnosis, body mass index, renal function, smoking status, lipid-lowering therapies and FVIIa levels. The APOC3 gene locus-tagging polymorphism rs964184, previously linked with cardiovascular risk and plasma lipids by genome-wide association studies, was associated with both ApoC-III and FVIIa-AT plasma concentration. Our results indicate a strong association between ApoC-III and FVIIa-AT levels, thereby suggesting that an increased ApoC-III concentration may identify subjects with a pro-thrombotic diathesis characterized by an enhanced TF-FVIIa interaction and activity. |
| Databáze: | OpenAIRE |
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