Association between inflammatory biomarkers and in-stent restenosis tissue features: an Optical Coherence Tomography Study
| Autor: | Mario Gramegna, Carlo Trani, Asiya Imaeva, Italo Porto, Giampaolo Niccoli, Marco Roberto, Ilaria Dato, Filippo Crea, Cristina Aurigemma, Roberta Antonazzo Panico, Antonio Maria Leone, Francesco Burzotta |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Neointima medicine.medical_specialty medicine.medical_treatment Population Urology Lumen (anatomy) Coronary Angiography Coronary Restenosis Optical coherence tomography Restenosis Risk Factors medicine Humans Radiology Nuclear Medicine and imaging education Aged Retrospective Studies education.field_of_study Eosinophil cationic protein optical coherence tomography medicine.diagnostic_test biology business.industry Eosinophil Cationic Protein C-reactive protein Stent Drug-Eluting Stents General Medicine in-stent restenosis medicine.disease C-Reactive Protein Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE biology.protein Female Stents Radiology Cardiology and Cardiovascular Medicine business Biomarkers Tomography Optical Coherence |
| Zdroj: | European Heart Journal - Cardiovascular Imaging. 15:917-925 |
| ISSN: | 2047-2412 2047-2404 |
| DOI: | 10.1093/ehjci/jeu035 |
| Popis: | Aims Inflammatory reaction after stent implantation is associated with in-stent restenosis (ISR). We assessed the association of optical coherence tomography (OCT) features of neointima with systemic levels of high-sensitivity C-reactive protein (hs-CRP) and eosinophil cationic protein (ECP) measured at the time of ISR detection. Methods and results Patients presenting with symptomatic angiographically documented ISR (diameter stenosis ≥50% by visual estimation) were included. Quantitative OCT analysis included the measurement of minimal lumen diameter, minimal luminal area, stent and neointimal area, stent and restenosis length, restenotic tissue burden, and symmetry ratio. Qualitative OCT analysis included the assessment of ISR plaque type, neointimal tissue structure, lumen shape, presence of microvessels and calcific nodules. At the time of ISR detection hs-CRP and ECP levels were measured, and statistical analysis was performed using as cut-off 3 mg/L and 4.5 µg/L, respectively. Our population included 40 patients, 24 bare metal stents and 16 drug-eluting stents. Patients with high hs-CRP levels had a higher restenostic tissue symmetry ratio (0.56 ± 0.17 vs. 0.42 ± 0.13, P = 0.01) when compared with patients with low hs-CRP levels. Patients with high ECP levels had a higher neointimal burden (70 ± 14 vs. 64 ± 11, P = 0.05) in comparison with patients with low ECP levels . Conclusions Inflammatory biomarkers assessed at the time of ISR detection are associated with different aspects of neointimal tissue. While hs-CRP seems to have a role in neointimal tissue shape, ECP is related to a neointimal burden. |
| Databáze: | OpenAIRE |
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