Effects of long-term continuous use of immune-enhancing enteral formula on nutritional and immunologic status in non-surgical patients
| Autor: | Shuhei Tonomura, Yasuko Nakamura, Ichiro Uyama, Toshihiko Masui, Ikuo Yoshida, Yoichi Sakurai, Mariko Hayakawa, Masahiro Ochiai, Yuriko Oh-oka, Shoji Mitsutaka, Shiho Kato, Yoshiyuki Komori, Sadamu Suzuki |
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| Rok vydání: | 2006 |
| Předmět: |
Ornithine
medicine.medical_specialty Docosahexaenoic Acids T-Lymphocytes Endocrinology Diabetes and Metabolism CD4-CD8 Ratio Nutritional Status Arginine Enteral administration Gastroenterology Blood Urea Nitrogen law.invention chemistry.chemical_compound 8 11 14-Eicosatrienoic Acid Enteral Nutrition Randomized controlled trial law Internal medicine Humans Medicine Lymphocyte Count Prospective Studies Insulin-Like Growth Factor I Food Formulated Gastrostomy B-Lymphocytes Nutrition and Dietetics business.industry Immunity Perioperative Eicosapentaenoic acid Interleukin-10 Uric Acid Surgery Killer Cells Natural Parenteral nutrition Eicosapentaenoic Acid chemistry Docosahexaenoic acid Uric acid business |
| Zdroj: | Nutrition. 22:713-721 |
| ISSN: | 0899-9007 |
| Popis: | Objective Although the perioperative use of immune-enhancing enteral formula (IEEF) effectively reduces the rate of infectious complications, whether chronic use of IEEF is beneficial is unknown. A prospective randomized clinical trial was performed to examine the safety and effectiveness of long-term IEEF on nutritional and immunologic status in non-surgical patients receiving total enteral nutrition through the gastrostomy access route. Methods A total of 30 patients were randomly assigned to two groups in which they received total enteral nutrition, an IEEF (n = 15) or a regular polymeric enteral formula (control group; n = 15) for 12 wk. Nutritional and immunologic variables were periodically examined. Results Serum concentrations of insulin-like growth factor-I increased significantly for the IEEF group throughout the study. Although serum concentrations of dihomo-γ-linoleic acid decreased significantly in the IEEF group, serum concentrations of eicosapentaenoic acid and docosahexaenoic acid increased significantly, as did concentrations of serum arginine and ornithine. The CD4/CD8 ratio and natural killer cell activity also increased for the IEEF group, but the differences were not significant. The B-cell fraction increased and the T-cell fraction of peripheral lymphocytes decreased for the IEEF group. Neither infectious nor non-infectious complications occurred during the study period in either group, except for a significant increase in serum urea nitrogen and uric acid concentrations for the IEEF group. Conclusion Long-term use of IEEF is safe in non-surgical patients and results in a significant increase in serum insulin-like growth factor-I concentrations in association with increased humoral immunity. |
| Databáze: | OpenAIRE |
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