Additional file 1 of Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner

Autor: Bachiller, S., Hidalgo, I., Garcia, M. G., Boza-Serrano, A., Paulus, A., Denis, Q., Haikal, C., Manouchehrian, O., Klementieva, O., Li, J. Y., Pronk, C. J., Gouras, G. K., Deierborg, T.
Rok vydání: 2022
Předmět:
DOI: 10.6084/m9.figshare.20080976
Popis: Additional file 1: Fig. S1. Microglia and Ab plaques are not affected by the MS in the hippocampal dentate gyrus, CA1 and CA3 areas and amygdala at 4 months old. (A) Representative microphotographs of microglia (Iba1: white; DAPI: blue) in a whole-brain section of 4 months old mice. Scale bar: 500 μm. Quantification of Iba1 + area relative to the total area in each section from 2–3 sections/animal in (B) dentate gyrus (DG), (C) CA1, (D) CA3 and (E) amygdala (n = 5–9 animals/group). (F) Representative Congo Red staining in a whole-brain section of 4 months 5xFAD mice (left) and (right) the total positive plaques/mm2 (n = 5–8 animals/group). Data are shown as mean ± SD. *P < 0.05.
Databáze: OpenAIRE