Homeostatic regulation of zinc absorption and endogenous losses in zinc-deprived men
| Autor: | Caroline M Taylor, I Bremner, P J Aggett, J R Bacon |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Diet therapy Medicine (miscellaneous) chemistry.chemical_element Endogeny Absorption (skin) Urine Zinc Absorption Pharmacokinetics Internal medicine medicine Homeostasis Humans Feces Nutrition and Dietetics Body Weight Alkaline Phosphatase Diet Endocrinology chemistry Energy Intake |
| Zdroj: | The American journal of clinical nutrition. 53(3) |
| ISSN: | 0002-9165 |
| Popis: | The mechanisms involved in the homeostatic regulation of zinc were studied in five male subjects by using stable 70Zn as a marker. When dietary zinc was reduced from 85 to 12 mumol/d, adaptation was achieved by a mean (+/- SEM) reduction in urine zinc of 48 +/- 7% and in fecal zinc of 46 +/- 12% over 25 d in four subjects. The latter was caused by an increase in the efficiency of zinc absorption from 38 +/- 3% to 93 +/- 1% after 15 d of zinic deprivation and by a reduction in intestinal endogenous losses of zinc. In a fifth subject, who had some evidence of a resolving alcohol-induced hepatitis, urine and fecal zinc were reduced by 64% and 41%, respectively, in 15 d and zinc absorption increased from 46% to 93%. More information on adaptive responses is needed to enable current dietary recommendations to be reconsidered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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