Prosomes discriminate between mRNA of adenovirus-infected and uninfected HeLa cells
| Autor: | Bistra Dineva, Ernst Spindler, Andrea Horsch, Cezar Martins de Sa, Hans-Peter Schmid |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Cytoplasm
mRNA translation Biophysics Biology Biochemistry Adenoviridae HeLa Structural Biology Genetics Animals Humans PAGE - Polyacrylamide gel electrophoresis RNA Messenger Molecular Biology Inhibition Messenger RNA RNA Nucleic Acid Hybridization Translation (biology) Differential regulation Cell Biology Prosome ScRNP complex biology.organism_classification Molecular biology In vitro Globins Molecular Weight Ribonucleoproteins Polyribosomes Protein Biosynthesis DNA Viral RNA Viral Electrophoresis Polyacrylamide Gel Rabbits Poly A HeLa Cells |
| Zdroj: | FEBS Letters. (1-2):131-136 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(89)80268-6 |
| Popis: | Prosomes are small cytoplasmic RNP complexes associated with repressed mRNA. In in vitro translation, they discriminate between the mRNA of adenovirus-infected HeLa cells and those of uninfected cells grown under normal conditions. Prosomes as well as their RNA constituents interact much more strongly with poly(A)+ mRNA of infected cells and inhibit their translation in vitro preferentially. A possible role of prosomes in the differential regulation of translation is discussed. |
| Databáze: | OpenAIRE |
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