Trypsin-induced masking of tetrodotoxin receptor of the sodium channels in mollusc neurones

Autor:	Nicholas K. Chemeris, L. S. Bocharova, Vitaliy I. Geletyuk
Rok vydání:	1980
Předmět:	Neurons Masking (art) Chemistry Receptors Drug musculoskeletal neural and ocular physiology Sodium channel Sodium Biophysics Tetrodotoxin Cell Biology Pronase Trypsin Biochemistry Ion Channels Papain chemistry.chemical_compound medicine Animals Tetrodotoxin receptor Lymnaea medicine.drug
Zdroj:	Biochimica et Biophysica Acta (BBA) - Biomembranes. 599:731-735
ISSN:	0005-2736
DOI:	10.1016/0005-2736(80)90213-8
Popis:	At the early stage of trypsin treatment of mollusc neurones tetrodotoxin cannot block the Na + current. In the course of further exposure of neurones to trypsin, tetrodotoxin-sensitivity is restored completely, so its temporal loss results from shielding rather than destruction of the tetrodotoxin-binding site. Pronase and papain do not affect the tetrodotoxin action on the Na + current.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c08729556ac8ce66ec3d5d960d354f https://doi.org/10.1016/0005-2736(80)90213-8 Zobrazit plný text záznamu