Association between ambulatory 24-hour blood pressure levels and brain volume reduction: a cross-sectional elderly population-based study
| Autor: | Robert Bartha, Frédéric Roche, Jean-Claude Barthélémy, Olivier Beauchet, Vincent Pichot, Sébastien Celle, Cédric Annweiler |
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| Přispěvatelé: | Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Ambulatory blood pressure Time Factors Brain/ pathology/physiopathology Blood Pressure 030204 cardiovascular system & hematology Brain mapping [SHS]Humanities and Social Sciences 03 medical and health sciences Cognition 0302 clinical medicine Blood Pressure Monitoring Internal Medicine Brodmann area 6 Medicine Humans Cognitive decline Antihypertensive Agents Cognition/physiology Aged Psychomotor Performance/physiology 2. Zero hunger Brain Mapping Antihypertensive Agents/therapeutic use Hypertension/drug therapy/physiopathology Magnetic Resonance Imaging/ methods business.industry Brain morphometry Brain Blood Pressure Monitoring Ambulatory Ambulatory/ methods Middle Aged Magnetic Resonance Imaging Pulse pressure Population Surveillance/methods Blood pressure Cross-Sectional Studies Blood Pressure/drug effects/ physiology Population Surveillance Anesthesia Hypertension Brain size Multivariate Analysis Linear Models Female business Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Hypertension (Dallas, Tex. : 1979) Hypertension (Dallas, Tex. : 1979), 2012, 60 (5), pp.1324-31. ⟨10.1161/hypertensionaha.112.193409⟩ |
| ISSN: | 1524-4563 |
| DOI: | 10.1161/hypertensionaha.112.193409⟩ |
| Popis: | International audience; Previous literature has shown mixed results regarding the association between blood pressure levels and brain volume reduction. The objectives of this study were to determine whether high blood pressure levels were associated with focal brain volume reduction and whether high blood pressure-related focal brain volume reduction was associated with a decline in executive function performance. On the basis of a cross-sectional design, 24-hour ambulatory blood pressure measurements, as well as brain morphology from 3-dimensional magnetic resonance images, were assessed among 183 participants (mean, 65 +/- 0.6 years; 62.4% women). Average levels of systolic and diastolic blood pressures, as well as dip, pulse pressure, and mean arterial blood pressure, were used as outcomes. Cortical gray and white matter volumes were determined by automatic calculation using Statistical Parametric Mapping segmentation. Folstein's Mini-Mental State Examination, digit span, part B of Trail Making, and Stroop tests were used to assess executive function performance. Sex, use of antihypertensive drugs, duration of hypertension, leukoaraiosis, body mass index, education level, and total brain matter volume were used as potential confounders. A significant blood pressure-related decrease in gray matter volume of the left supplementary motor areas (Brodmann area 6) and of the left superior and middle frontal gyrus (Brodmann area 8) was shown. No significant decrease was found with white matter volume. Blood pressure-related decreases in gray matter volume were significantly associated with a decline in executive function performance. The association of high blood pressure with brain volume reduction may in part explain blood pressure-related cognitive decline leading to dementia. |
| Databáze: | OpenAIRE |
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