The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis

Autor: Martinez-Perez, Oscar, Prats Rodriguez, Pilar, Muner Hernandez, Marta, Encinas Pardilla, Maria Begoña, Perez Perez, Noelia, Vila Hernandez, Maria Rosa, Villalba Yarza, Ana, Nieto Velasco, Olga, Del Barrio Fernandez, Pablo Guillermo, Forcen Acebal, Laura, Orizales Lago, Carmen Maria, Martinez Varea, Alicia, Muñoz Abellana, Begoña, Suarez Arana, Maria, Fuentes Ricoy, Laura, Martinez Diago, Clara, Janeiro Freire, Maria Jesus, Alférez Alvarez-Mallo, Macarena, Casanova Pedraz, Cristina, Alomar Mateu, Onofre, Lesmes Heredia, Cristina, Wizner de Alva, Juan Carlos, Bernardo Vega, Rut, Macia Badia, Montserrat, Alvarez Colomo, Cristina, Sanchez Muñoz, Antonio, Pratcorona Alicart, Laia, Alonso Saiz, Ruben, Lopez Rodriguez, Monica, Del Carmen Barbancho Lopez, Maria, Meca Casbas, Marta Ruth, Vaquerizo Ruiz, Oscar, Moran Antolin, Eva, Nuñez Valera, Maria Jose, Fernandez Fernandez, Camino, Tubau Navarra, Albert, Cano Garcia, Alejandra Maria, Baena Luque, Carmen, Soldevilla Perez, Susana, Gastaca Abasolo, Irene, Adanez Garcia, Jose, Teulon Gonzalez, Maria, Puertas Prieto, Alberto, Ostos Serna, Rosa, Del Pilar Guadix Martin, Maria, Catalina Coello, Monica, Ferriols Perez, Elena, Caño Aguilar, Africa, De la Cruz Conty, Maria Luisa, Sainz Bueno, Jose Antonio, Spanish Obstetric Emergency Group
Přispěvatelé: Servicio de Ginecología. Hospital Universitario de Fuenlabrada
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Fetal Membranes
Premature Rupture
Neonatal intensive care unit
Epidemiology
viruses
Complicaciones Infecciosas del Embarazo
0302 clinical medicine
Pregnancy
Odds Ratio
030212 general & internal medicine
Prospective Studies
Pregnancy Complications
Infectious
Prospective cohort study
030219 obstetrics & reproductive medicine
Intensive care units
Obstetrics
Premature rupture of membranes
Obstetrics and Gynecology
Gestational age
virus diseases
Middle Aged
Nacimiento Prematuro
epidemiología
Premature birth
Infant
Extremely Premature
Female
Coronavirus Infections
Infant
Premature
Research Article
Adult
medicine.medical_specialty
Adolescent
Gestational Age
lcsh:Gynecology and obstetrics
neonatal
03 medical and health sciences
Young Adult
Intensive Care Units
Neonatal
medicine
Humans
Labor
Induced
lcsh:RG1-991
business.industry
Rotura Prematura de Membranas Fetales
SARS-CoV-2
Cesarean Section
Case-control study
Infant
Newborn
COVID-19
Odds ratio
medicine.disease
Coronavirus
Logistic Models
Spain
Case-Control Studies
Multivariate Analysis
business
Infecciones por Coronavirus
Zdroj: BMC Pregnancy and Childbirth
BMC PREGNANCY AND CHILDBIRTH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
BMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-11 (2021)
ISSN: 1471-2393
Popis: Background To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of COVID-19 disease) exposure in pregnancy, compared to non-exposure, is associated with infection-related obstetric morbidity. Methods We conducted a multicentre prospective study in pregnancy based on a universal antenatal screening program for SARS-CoV-2 infection. Throughout Spain 45 hospitals tested all women at admission on delivery ward using polymerase-chain-reaction (PCR) for COVID-19 since late March 2020. The cohort of positive mothers and the concurrent sample of negative mothers was followed up until 6-weeks post-partum. Multivariable logistic regression analysis, adjusting for known confounding variables, determined the adjusted odds ratio (aOR) with 95% confidence intervals (95% CI) of the association of SARS-CoV-2 infection and obstetric outcomes. Main outcome measures: Preterm delivery (primary), premature rupture of membranes and neonatal intensive care unit admissions. Results Among 1009 screened pregnancies, 246 were SARS-CoV-2 positive. Compared to negative mothers (763 cases), SARS-CoV-2 infection increased the odds of preterm birth (34 vs 51, 13.8% vs 6.7%, aOR 2.12, 95% CI 1.32–3.36, p = 0.002); iatrogenic preterm delivery was more frequent in infected women (4.9% vs 1.3%, p = 0.001), while the occurrence of spontaneous preterm deliveries was statistically similar (6.1% vs 4.7%). An increased risk of premature rupture of membranes at term (39 vs 75, 15.8% vs 9.8%, aOR 1.70, 95% CI 1.11–2.57, p = 0.013) and neonatal intensive care unit admissions (23 vs 18, 9.3% vs 2.4%, aOR 4.62, 95% CI 2.43–8.94, p Conclusion This prospective multicentre study demonstrated that pregnant women infected with SARS-CoV-2 have more infection-related obstetric morbidity. This hypothesis merits evaluation of a causal association in further research.
Databáze: OpenAIRE
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