Circadian rhythm of brain susceptibility to haloperidol during chronic administration
| Autor: | Haruo Nagayama, Akinori Takagi, Kenzaburo Nishiwaki, Ryo Takahashi, S. Yoshimoto, H. Minami |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Time Factors Apomorphine medicine.medical_treatment Clinical Biochemistry Pharmacology Toxicology Biochemistry Behavioral Neuroscience medicine Haloperidol Animals Humans Circadian rhythm Biological Psychiatry business.industry Chronotherapy (sleep phase) Brain Rats Inbred Strains Circadian Rhythm Rats Brain level Stereotyped Behavior Once daily business medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 16:311-314 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(82)90165-4 |
| Popis: | Circadian fluctuation has been reported to exist to the effects of haloperidol after acute administration. In an attempt to clarify the viability of chronotherapy with haloperidol, the antiapomorphine effect of haloperidol after chronic administration was investigated in the present paper. Haloperidol was administered once daily at the same time for 21 consecutive days to rats which were kept under 12 hr lighting conditions with light onset at 19:30. Then the chronology of the antiapomorphine effect was investigated. The antiapomorphine effect was significantly stronger in the group treated at 19:30 than that treated at 13:30. These data agreed with the results found after the acute administration of the drug. After chronic administration, no difference was found in the plasma and brain level of haloperidol due to the time of administration. These experimental results seem to suggest that a circadian rhythm in the brain susceptibility to haloperidol exists even during chronic administration. |
| Databáze: | OpenAIRE |
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