A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities

Autor: Yang Chunguang, Huaibo Tang, Liang Qin, Chunyan Li, Ping Wu, Hongsuo Liang, Pei Feng, Cijun Shuai
Rok vydání: 2017
Předmět:
Male
Lipopolysaccharide
analgesic activities
Anti-Inflammatory Agents
Pharmacology
lcsh:Chemistry
Mice
chemistry.chemical_compound
Drug Delivery Systems
0302 clinical medicine
Oral administration
Edema
Prostaglandin E2
lcsh:QH301-705.5
Cells
Cultured
Spectroscopy
anti-inflammatory
Transdermal
Analgesics
Strychnine
General Medicine
Synoviocytes
Computer Science Applications
brucine gel
transdermal delivery
030220 oncology & carcinogenesis
Rheumatoid arthritis
medicine.drug
Cell Survival
medicine.drug_class
Analgesic
Pain
Administration
Cutaneous
Dinoprostone
Article
Catalysis
Anti-inflammatory
Cell Line
Inorganic Chemistry
03 medical and health sciences
Formaldehyde
medicine
Animals
Humans
Rats
Wistar
Physical and Theoretical Chemistry
Molecular Biology
Cell Proliferation
Brucine
business.industry
Macrophages
Organic Chemistry
Strychnos nux-vomica
medicine.disease
Arthritis
Experimental
Disease Models
Animal
lcsh:Biology (General)
lcsh:QD1-999
chemistry
business
Gels
030217 neurology & neurosurgery
Phytotherapy
Zdroj: International Journal of Molecular Sciences, Vol 18, Iss 4, p 757 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 757
International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: 10.3390/ijms18040757
Popis: The seeds of Strychnos nux-vomica L., as a traditional Chinese medicine, have good anti-inflammatory and analgesic activities. However, it usually leads to gastrointestinal irritation and systemic toxicity via oral administration. In the study, it was discovered that a novel gel transdermal delivery system contained brucine, the main effective component extracted from Strychnos nux-vomica. Results showed that the brucine gel system inhibited arthritis symptoms and the proliferation of the synoviocytes in the rat adjuvant arthritis model, which indicated its curative effect for rheumatoid arthritis. Meanwhile, it significantly relieved the xylene-induced ear edema in the mouse ear swelling test, which manifested its anti-inflammatory property. Moreover, the brucine gel eased the pain of paw formalin injection in the formalin test, which demonstrated its analgesic effects. In addition, the brucine significantly inhibited lipopolysaccharide (LPS)-induced Prostaglandin E2 (PGE2) production without affecting the viability of cell in vitro anti-inflammatory test, which proved that its anti-inflammatory and analgesic actions were related to inhibition of prostaglandin synthesis. It is suggested that the brucine gel is a promising vehicle for transdermal delivery on the treatment of inflammatory disease.
Databáze: OpenAIRE
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