Hippocampal effects of neuronostatin on memory, anxiety-like behavior and food intake in rats
| Autor: | Marisa S. Ghersi, S. R. De Barioglio, Laura Gabach, Oscar A. Ramirez, Valeria P. Carlini, Mariela F Pérez, M. Fiol de Cuneo, Helgi B. Schiöth |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Food intake Patch-Clamp Techniques medicine.drug_class Long-Term Potentiation Hippocampal formation Anxiety Anxiolytic Hippocampus Eating Memory Internal medicine medicine Animals Rats Wistar Maze Learning NEURONOSTATIN Third ventricle General Neuroscience Long-term potentiation Impaired memory Peptide Fragments Rats medicine.anatomical_structure Endocrinology Somatostatin Psychology Neuroscience |
| Zdroj: | Neuroscience. 197 |
| ISSN: | 1873-7544 |
| Popis: | A 13-amino acid peptide named neuronostatin (NST) encoded in the somatostatin pro-hormone has been recently reported. It is produced throughout the body, particularly in brain areas that have significant actions over the metabolic and autonomic regulation. The present study was performed in order to elucidate the functional role of NST on memory, anxiety-like behavior and food intake and the hippocampal participation in these effects. When the peptide was intra-hippocampally administered at 3.0 nmol/μl, it impaired memory retention in both, object recognition and step-down test. Also, this dose blocked the hippocampal long-term potentiation (LTP) generation. When NST was intra-hippocampally administered at 0.3 nmol/μl and 3.0 nmol/μl, anxiolytic effects were observed. Also, the administration in the third ventricle at the higher dose (3.0 nmol/μl) induced similar effects, and both doses reduced food intake. The main result of the present study is the relevance of the hippocampal formation in the behavioral effects induced by NST, and these effects could be associated to a reduced hippocampal synaptic plasticity. |
| Databáze: | OpenAIRE |
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