KRAS Mutation in Serous Borderline Tumor of the Testis: Report of a Case and Review of the Literature

Autor:	Ilyas Svistakov, Walid Al Hajj Obeid, Xavier Catteau, Sandrine Rorive, Jean Christophe Noël, Thierry Roumeguere, Sarah Bouri, Nicky D'Haene
Rok vydání:	2020
Předmět:	0303 health sciences Pathology medicine.medical_specialty endocrine system diseases Psammoma body business.industry medicine.drug_class Case Report General Medicine Diseases of the genitourinary system. Urology female genital diseases and pregnancy complications 03 medical and health sciences Cytokeratin Serous fluid 0302 clinical medicine KRAS Gene Mutation Estrogen 030220 oncology & carcinogenesis Mutation testing Medicine RC870-923 business PAX8 Gene 030304 developmental biology
Zdroj:	Case Reports in Urology Case Reports in Urology, Vol 2020 (2020)
ISSN:	2090-6978 2090-696X
DOI:	10.1155/2020/5419707
Popis:	Ovarian-like epithelial tumors of the testis, including serous borderline tumors, are rare entities. We report the case of a 60-year-old man with a left intratesticular mass who had a radical orchidectomy. Histologically, the tumor was identical to the ovarian counterpart showing a well-delineated cystic lesion characterized by intraluminal papillae. The papillae are lined by atypical cuboidal or ciliated cells and are associated with psammoma bodies. The tumor cells express cytokeratin 7 (CK7), cytokeratin 5-6 (CK5-6), cancer antigen 125 (CA125), estrogen (ER), progesterone (PR), Wilm’s tumor gene (WT1), paired box gene 8 (PAX8), Ber-EP4, and epithelial membrane antigen (EMA). The diagnosis of a serous borderline tumor of the testis was proposed. Mutation testing using next-generation sequencing showed a Q61K KRAS gene mutation. To the best of our knowledge, this is the second case report of a serous borderline tumor of the testis with a Q61K KRAS gene mutation.
Databáze:	OpenAIRE
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