CEA, MCA, CA 15.3 and CA 549 and their combinations in expressing and monitoring metastatic breast cancer: a prospective comparative study
| Autor: | Franco Pannuti, Claudio Zamagni, L. Zanichelli, B. Bellanova, F. Vecchi, Andrea Martoni, Elena Strocchi, N. Cacciari |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty CA 15-3 Breast Neoplasms Sensitivity and Specificity Carcinoembryonic antigen Antigen Antigens Neoplasm Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Humans Antigens Tumor-Associated Carbohydrate In patient Prospective Studies Neoplasm Metastasis Prospective cohort study Objective response Aged Aged 80 and over Baseline values biology business.industry Middle Aged medicine.disease Metastatic breast cancer Carcinoembryonic Antigen biology.protein Female business Follow-Up Studies |
| Zdroj: | European Journal of Cancer. 31:1615-1621 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/0959-8049(95)00340-o |
| Popis: | Serum levels of carcinoembryonic antigen (CEA), mucin-like carcinoma-associated antigen (MCA), CA 15.3 and CA 549 were concurrently assayed in patients with metastatic breast cancer. Overall sensitivity in detecting metastatic breast cancer (201 pts) was CEA 45%, MCA 59%, CA 15.3 71% and CA 549 72% (P < 0.01). Sensitivity increased by only 6% to 8% when two or more antigens were simultaneously considered. An overall sensitivity of correlation with objective response (n = 71) was observed in the range of 53-67% (P = n.s.) in patients with abnormal baseline marker values, and in the range of 42-87% (P < 0.05) in patients with normal baseline values. The combination of two or more markers did not improve sensitivity, but decreased specificity of correlation with objective response. In conclusion, CA 15.3 and CA 549 have individually higher sensitivity in detecting metastatic breast cancer. No clinical advantage was observed for using two or more markers concurrently over CA 15.3 or CA 549 alone in the monitoring of metastatic breast cancer. |
| Databáze: | OpenAIRE |
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