Marine Sediment Recovered Salinispora sp. Inhibits the Growth of Emerging Bacterial Pathogens and other Multi-Drug-Resistant Bacteria

Autor: Sergio Martínez-García, Luis A. Maldonado, Bárbara González-Acosta, Erika T. Quintana, Juan C. Cancino-Diaz, Sergio F. Martínez-Díaz, Claudia J. Hernández-Guerrero, Luis Contreras-Castro
Rok vydání: 2020
Předmět:
MLSA
0106 biological sciences
0301 basic medicine
Geologic Sediments
lcsh:QR1-502
medicine.disease_cause
01 natural sciences
Applied Microbiology and Biotechnology
lcsh:Microbiology
Staphylococcus epidermidis
Drug Resistance
Multiple
Bacterial
RNA
Ribosomal
16S
Punta Arena de la Ventana
Phylogeny
Salinispora
biology
transport planning
Micromonosporaceae
Decision Support System
General Medicine
Enterobacter
Anti-Bacterial Agents
Actinobacteria
Staphylococcus aureus
multi-drug-resistant bacteria
Microbiology (medical)
lcsh:QH426-470
030106 microbiology
Microbiology
emerging bacterial pathogens
03 medical and health sciences
Bacterial Proteins
010608 biotechnology
Antibiosis
medicine
quantitative methods
Humans
Seawater
Mexico
Salinispora arenicola
Bacteria
Pseudomonas aeruginosa
sustainable mobility
biology.organism_classification
lcsh:Genetics
Culture Media
Conditioned
Enterococcus faecium
Zdroj: Polish Journal of Microbiology
Polish Journal of Microbiology, Vol 69, Iss 3 (2020)
ISSN: 2544-4646
Popis: Marine obligate actinobacteria produce a wide variety of secondary metabolites with biological activity, notably those with antibiotic activity urgently needed against multi-drug-resistant bacteria. Seventy-five marine actinobacteria were isolated from a marine sediment sample collected in Punta Arena de La Ventana, Baja California Sur, Mexico. The 16S rRNA gene identification, Multi Locus Sequence Analysis, and the marine salt requirement for growth assigned seventy-one isolates as members of the genus Salinispora, grouped apart but related to the main Salinispora arenicola species clade. The ability of salinisporae to inhibit bacterial growth of Staphylococcus epidermidis, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacer baumannii, Pseudomonas aeruginosa, and Enterobacter spp. was evaluated by cross-streaking plate and supernatant inhibition tests. Ten supernatants inhibited the growth of eight strains of S. epidermidis from patients suffering from ocular infections, two out of the eight showed growth inhibition on ten S. epidermidis strains from prosthetic joint infections. Also, it inhibited the growth of the remaining six multi-drug-resistant bacteria tested. These results showed that some Salinispora strains could produce antibacterial compounds to combat bacteria of clinical importance and prove that studying different geographical sites uncovers untapped microorganisms with metabolic potential.
Databáze: OpenAIRE
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