Clinical Outcomes of Post-exposure Prophylaxis following Occupational Exposure to Human Immunodeficiency Virus at Dental Departments of Hiroshima University Hospital
| Autor: | T Shintani, T Fujii, M Nakaoka, M Okada, T Iwata, N Yamasaki, Hideki Shiba |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
U=U
Adult Male medicine.medical_specialty Sexual transmission Anti-HIV Agents Needlestick injury medicine.medical_treatment Dentists Human immunodeficiency virus (HIV) HIV Infections occupational exposures medicine.disease_cause Article Hospitals University 03 medical and health sciences 0302 clinical medicine dental treatment Japan Risk Factors Occupational Exposure Virology needlestick injury medicine Humans 030212 general & internal medicine Post-exposure prophylaxis Needlestick Injuries Retrospective Studies business.industry Dental Clinics HIV Retrospective cohort study 030206 dentistry Middle Aged University hospital medicine.disease Infectious Diseases Increased risk Anti-Retroviral Agents post-exposure prophylaxis Emergency medicine Female Occupational exposure business |
| Zdroj: | Current HIV Research |
| ISSN: | 1570-162X |
| DOI: | 10.2174/1570162x18666200804151118 |
| Popis: | Background: Dental professionals have so many opportunities to use injection needles and sharp instruments during dental treatment that they face an increased risk of needlestick injuries. This retrospective study reports the utilization and clinical outcomes of occupational post-exposure prophylaxis (PEP) with anti-retroviral agents after being potentially exposed to HIV at dental departments of Hiroshima University Hospital. Objective: This study reports the utilization and clinical outcomes of occupational post-exposure prophylaxis (PEP) with anti-retroviral agents after being potentially exposed to HIV at dental departments of Hiroshima University Hospital. Methods: Data on the clinical status of HIV-infected source patients and information on HIV-exposed dental professionals from 2007 to 2018 were collected. Results: Five dentists with an average experience of 5.6 years (1-15 years) were exposed. The averaged CD4-positive cell number and HIV-RNA load were 1176 (768-1898) / l and less than 20 copies/ml, respectively, in all the patients. Two of the five HIV exposed dentists received PEP. Three months after the exposures, all of their results were negative in HIV antibody/antigen tests. Conclusion: These data might support the concept of “undetectable equals untransmittable”, although HIV exposure in this study was not through sexual transmission. |
| Databáze: | OpenAIRE |
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