Correlation of serum immunoglobulin E elevations with clinical stages of dysthyroid orbitopathy
| Autor: | Milton H. Dalbow, R. B. Raikow, Michael Kazim, John S. Kennerdell, D Scalise, Anna Tyutyunikov |
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| Rok vydání: | 1992 |
| Předmět: |
Autoimmune disease
medicine.medical_specialty Allergy biology business.industry Eye disease Enzyme-Linked Immunosorbent Assay Immunoglobulin E medicine.disease Gastroenterology Pathophysiology Graves Disease Ophthalmology Internal medicine Immunopathology Immunology medicine biology.protein Humans medicine.symptom Complication Myopathy business |
| Zdroj: | Ophthalmology. 99(3) |
| ISSN: | 0161-6420 |
| Popis: | Total immunoglobulin E (IgE) was measured by an enzyme-linked immunoassay in serum samples from patients with dysthyroid orbitopathy and from a group of healthy volunteers. All the serum donors had no symptoms of allergy or infection and were not given any immunoregulative treatments for at least 6 months before the sampling. One hundred thirty-seven dysthyroid orbitopathy patients were rated clinically as belonging to one of the following groups: (1) stable dysthyroid orbitopathy; (2) active dysthyroid orbitopathy; (3) chronic or recurrent dysthyroid orbitopathy; or (4) dysthyroid orbitopathy characterized by limited myopathy. The serum IgE levels of all these groups were compared with 26 healthy, nonatopic volunteers. The mean IgE levels of groups 3 and 4 were significantly higher than the mean IgE level of the control group as well as that of the group with stable dysthyroid orbitopathy. Furthermore, serial readings on several patients were consistent with the hypothesis that serum IgE is elevated in connection with certain stages of rapid dysthyroid orbitopathy progression and also with two unusual clinical forms of dysthyroid orbitopathy. |
| Databáze: | OpenAIRE |
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