Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils
| Autor: | Véronique Mathieu, Véronique Fontaine, Florence Souard, Dominique Baudoux, Sofia Oliveira Ribeiro, Caroline Stevigny, Abdesselam Zhiri |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) food.ingredient Lavender medicine.drug_class 030106 microbiology Antibiotics German Chamomile MRSA Biology Biochemistry Microbiology Article essential oil law.invention 03 medical and health sciences food Antibiotic resistance antibacterial activity law medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Essential oil Chinese cinnamon Traditional medicine lcsh:RM1-950 bacterial resistance Penicillin lcsh:Therapeutics. Pharmacology 030104 developmental biology Infectious Diseases bacterial infections cytotoxicity Antibacterial activity medicine.drug |
| Zdroj: | Antibiotics Volume 9 Issue 10 Antibiotics, Vol 9, Iss 717, p 717 (2020) |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics9100717 |
| Popis: | There is a huge concern in the medical field concerning the emergence of bacterial resistance to antibiotics. Essential oils are a source of antibacterial compounds that can overcome this problem. Ten essential oils that are commercially available were investigated in the present study: ajowan, basil, German chamomile, Chinese cinnamon, coriander, clove, lemongrass, Spanish lavender, oregano and palmarosa. Their direct, synergistic and indirect antibacterial activities were evaluated against different human pathogenic Gram-positive and Gram-negative strains. To evaluate their possible use in clinics, the cytotoxicity of these essential oils was also tested on keratinocyte and epithelial cell lines. Except for the Chinese cinnamon, coriander and lemongrass, all other essential oils presented no cytotoxicity at 32 and 16 &mu g/mL. The highest indirect antibacterial activities were observed with the palmarosa and Spanish lavender in association with penicillin V. These two associations presented a 64-fold decrease against a resistant strain of Staphylococcus aureus, however, at a cytotoxic concentration. It can also be highlighted that when tested at a non-cytotoxic concentration, the activity of oregano in association with penicillin V presented an eight-fold decrease. These results show the interest to use essential oils in combination with antibiotics to reduce their concentrations inside drugs. |
| Databáze: | OpenAIRE |
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