Virucidal activity of Garcinia parvifolia leaf extracts in animal cell culture
| Autor: | Homayoun Hani, Rasedee Abdullah, Aziera Adnan, Zeenathul Nazariah Allaudin, Teng-Jin Khoo, Hwei-San Loh, Kang Nee Ting |
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| Rok vydání: | 2019 |
| Předmět: |
Antioxidant
medicine.medical_treatment Ethyl acetate Viral Plaque Assay Acetates Antiviral Agents Virucidal assay Pseudorabies virus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cytopathic effect reduction assay Chlorocebus aethiops medicine Animals Potency Garcinia Cytotoxicity Vero Cells Cytopathic effect Infectivity Ethanol Plaque reduction assay biology Traditional medicine Plant Extracts Chemistry lcsh:Other systems of medicine General Medicine lcsh:RZ201-999 biology.organism_classification Herpesvirus 1 Suid Inhibition assay 030205 complementary & alternative medicine Complementary and alternative medicine 030220 oncology & carcinogenesis Vero cell Selectivity index Hexane Research Article |
| Zdroj: | BMC Complementary and Alternative Medicine BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-10 (2019) |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/s12906-019-2586-5 |
| Popis: | Background Garcinia species contain bioactive compounds such as flavonoids, xanthones, triterpernoids, and benzophenones with antibacterial, antifungal, anti-inflammatory, and antioxidant activities. In addition, many of these compounds show interesting biological properties such as anti-human immunodeficiency virus activity. Garcinia parvifolia is used in traditional medicine. Currently, the antiviral activity of G. parvifolia is not known. Methods This study was conducted to determine the effects of ethyl acetate (45 L Ea), ethanol (45 L Et), and hexane (45 L H) leaf extracts of G. parvifolia on the infectivity of pseudorabies virus (PrV) in Vero cells. The antiviral effects of the extracts were determined by cytopathic effect (CPE), inhibition, attachment, and virucidal assays. Results The 50% cytotoxicity concentration (CC50) values obtained were 237.5, 555.0, and |
| Databáze: | OpenAIRE |
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