Acute toxic effects of sodium selenate on the epiphyseal plate of the rat
| Autor: | Robert J. Bielen, Robert D. Campo |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Epiphyseal plate Chondrosarcoma chemistry.chemical_element Selenate Selenium chemistry.chemical_compound Endocrinology Polysaccharides Internal medicine Sulfur Isotopes medicine Animals Orthopedics and Sports Medicine Age Factors General Medicine medicine.disease Rats Sodium selenate Cartilage medicine.anatomical_structure chemistry Epiphysis Protein Biosynthesis Autoradiography Epiphyses |
| Zdroj: | Calcified Tissue Research. 7:318-330 |
| ISSN: | 1432-0827 0008-0594 |
| DOI: | 10.1007/bf02062621 |
| Popis: | Severe histopathological irregularities in the epiphyseal plates of rats became evident following three daily injections of sublethal amounts of sodium selenate. If administered on alternate days over a thirty-day period, the pathological effects are less pronounced. The articular cartilages are unaffected by the selenate. An attempt was made to influence a transplantable murine chondrosarcoma by chronic administration of sodium selenate to tumorbearing mice. The sodium selenate had no effect on the tumor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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