Variation in exposure to Anopheles gambiae salivary gland peptide (gSG6-P1) across different malaria transmission settings in the western Kenya highlands

Autor: Kingsley Badu, Franck Remoue, Guofa Zhou, John M. Ong’echa, Guiyun Yan, Bernard W. Lawson, Andrew K. Githeko, John A. Larbi, Yaw A. Afrane, Joram Siangla
Rok vydání: 2012
Předmět:
Veterinary medicine
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Anopheles gambiae
Plasmodium falciparum
030231 tropical medicine
Population
Antibodies
Protozoan
Host-Parasite Interactions
lcsh:Infectious and parasitic diseases
law.invention
Serology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Seroepidemiologic Studies
law
Anopheles
parasitic diseases
Animals
Humans
Seroprevalence
lcsh:RC109-216
Malaria
Falciparum
Salivary Proteins and Peptides
education
Merozoite Surface Protein 1
030304 developmental biology
0303 health sciences
education.field_of_study
biology
Research
biology.organism_classification
Kenya
Insect Vectors
3. Good health
Cross-Sectional Studies
Infectious Diseases
Transmission (mechanics)
Parasitology
Immunoglobulin G
Epidemiological Monitoring
Immunology
Insect Proteins
Seasons
Zdroj: Badu, Kingsley; Siangla, Joram; Larbi, John; Lawson, Bernard W; Afrane, Yaw; Ong’echa, John; et al.(2012). Variation in exposure to Anopheles gambiae salivary gland peptide (gSG6-P1) across different malaria transmission settings in the western Kenya highlands. Malaria Journal, 11(1), 318. doi: http://dx.doi.org/10.1186/1475-2875-11-318. Retrieved from: http://www.escholarship.org/uc/item/4362m53v
Malaria Journal, Vol 11, Iss 1, p 318 (2012)
Malaria Journal
ISSN: 1475-2875
DOI: 10.1186/1475-2875-11-318
Popis: Background The existing metrics of malaria transmission are limited in sensitivity under low transmission intensity. Robust surveillance systems are needed as interventions to monitor reduced transmission and prevention of rapid reintroduction. Serological tools based on antibody responses to parasite and vector antigens are potential tools for transmission measurements. The current study sought to evaluate antibody responses to Anopheles gambiae salivary gland peptide (gSG6- P1), as a biomarker of human exposure to Anopheles bites, in different transmission settings and seasons. The comparison between anti-MSP-119 IgG immune responders and non-responders allowed exploring the robustness of the gSG6-P1 peptide as a surveillance tool in an area of decreasing malaria transmission. Methods Total IgG levels to gSG6-P1 were measured in an age-stratified cohort (< 5, 5–14 and ≥ 15 years) in a total of 1,366 participants from three localities in western Kenya [Kisii (hypoendemic), Kakamega (mesoendemic), and Kombewa (hyperendemic)] including 607 sera that were additionally tested for MSP-119 specific responses during a low and a high malaria transmission seasons. Antibody prevalence and levels were compared between localities with different transmission intensities. Regression analysis was performed to examine the association between gSG6-P1 and MSP-119 seroprevalence and parasite prevalence. Result Seroprevalence of gSG6-P1 in the uphill population was 36% while it was 50% valley bottom (χ2 = 13.2, df = 1, p
Databáze: OpenAIRE
Externí odkaz: