Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats
| Autor: | Julie Oluranti Akinyele, Oluwatosin A. Adetuyi, Olubanke Olujoke Ogunlana, Oluseyi E. Ogunlana, Oluwaseun A. Adebisi, Alaba Oladipupo Adeyemi, Miracle Rotimi, lohor Esalomi, Edward K. Opata, Roua S. Baty, Gaber El-Saber Batiha, Babatunde O. Adetuyi |
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| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
endocrine system diseases medicine.medical_treatment 030232 urology & nephrology Pharmacology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Hunteria Diabetes mellitus Medicine 030304 developmental biology General Environmental Science 0303 health sciences biology Streptozotocin business.industry Insulin Diabetes RX1-681 Hunteria umbellate Homeopathy biology.organism_classification medicine.disease Metformin hypoglycemic Phytochemical Fasting blood glucose General Earth and Planetary Sciences business Oxidative stress medicine.drug |
| Zdroj: | Clinical Phytoscience, Vol 7, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2199-1197 |
| DOI: | 10.1186/s40816-021-00285-1 |
| Popis: | Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats. |
| Databáze: | OpenAIRE |
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