The relationship between full field electroretinogram and perimetry-like visual thresholds in RCS rats during photoreceptor degeneration and rescue by cell transplants
| Autor: | Y. Sauve, Raymond D. Lund, Bin Lu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Retinal degeneration
medicine.medical_specialty genetic structures Dark Adaptation Biology 03 medical and health sciences 0302 clinical medicine Optics Ophthalmology Electroretinography medicine Animals Pigment Epithelium of Eye Superior colliculus Transplantation Retina medicine.diagnostic_test business.industry Visual field perimetry medicine.disease eye diseases Sensory Systems Rats Visual field medicine.anatomical_structure Receptive field ERG Models Animal 030221 ophthalmology & optometry sense organs Visual Fields business Erg Retinitis Pigmentosa 030217 neurology & neurosurgery |
| Zdroj: | Vision Research. 44:9-18 |
| ISSN: | 0042-6989 |
| Popis: | Dark-adapted full field electroretinogram (ERG) and visual receptive field thresholds (recorded from the superior colliculus) were correlated in a model of retinal degeneration, the Royal College of Surgeons rat. In both untreated and retinal pigment epithelium cell transplanted rats, optimal correlation was between b-wave amplitude and preserved visual field area with thresholds under a defined level.The work shows that the magnitude of the b-wave can be used to predict the computed area and degree of visual field preservation recorded in the central nervous system. These observations validate using ERG to assess residual visual function and the effect of transplantation. |
| Databáze: | OpenAIRE |
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