Effect of βh-Endorphin on Release of Insulin by Rabbit Pancreas in Response to Four Secretagogues: Comparison with Somatostatin and Epinephrine
| Autor: | Kutner Mh, Rudman D |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
endocrine system
medicine.medical_specialty Epinephrine Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Peptide hormone Biology Biochemistry Endocrinology Phentolamine Internal medicine Insulin Secretion medicine Animals Insulin Endorphins Pancreas Naloxone beta-Endorphin Biochemistry (medical) General Medicine medicine.anatomical_structure Somatostatin Secretagogue Rabbits hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 18:365-368 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-1012318 |
| Popis: | Previous work showed beta h-endorphin inhibits glucose-stimulated secretion of insulin by rabbit pancreas slices. This study, also conducted with rabbit pancreas slices, compared the antisecretagogue actions of beta h-endorphin, somatostatin 1-14, and epinephrine versus four secretagogues, glucose, mannose, leucine and potassium chloride. All three antisecretagogues inhibited all four secretagogues. The order of potency of the antisecretagogues varied according to secretagogue. Naloxone antagonized only beta h-endorphin among the three antisecretagogues, and phentolamine antagonized only epinephrine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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