Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications

Autor: Jean Villard, Eddy Roosnek, Laurent Kaiser, Steffen Walter, Solange Vischer, Yves Chalandon, Lionel Arlettaz, René A. W. van Lier, Sylvie Degermann, Claudine Helg, Mirjam H.M. Heemskerk, Bernard Chapuis
Přispěvatelé: Faculteit der Geneeskunde, Landsteiner Laboratory, Experimental Immunology
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Adult
Cellular immunity
Cytomegalovirus/ immunology
T cell
T-Lymphocytes
Immunology
Hematologic Neoplasms/complications/therapy
Cytomegalovirus
Cytomegalovirus Infections/complications/immunology/prevention & control
T-Cell Antigen Receptor Specificity
Biochemistry
Lymphocyte Depletion
Mice
Antigen
Immunity
medicine
Lymphocyte Transfusion/ methods
Cytotoxic T cell
Animals
Humans
Retrospective Studies
ddc:616
T-Lymphocytes/immunology/ transplantation
business.industry
T-Cell Antigen Receptor Specificity/immunology
Hematopoietic Stem Cell Transplantation
virus diseases
Cell Biology
Hematology
T lymphocyte
Middle Aged
Transplantation
medicine.anatomical_structure
Hematopoietic Stem Cell Transplantation/adverse effects/ methods
Treatment Outcome
Hematologic Neoplasms
Lymphocyte Transfusion
Cytomegalovirus Infections
Stem cell
business
Zdroj: Blood, Vol. 107, No 1 (2006) pp. 389-396
Blood, 107(1), 389-396. American Society of Hematology
ISSN: 0006-4971
DOI: 10.1182/blood-2005-07-2746
Popis: We have studied cytomegalovirus (CMV) immunity in 17 CMV-positive recipients of T-cell-depleted or T-cell-replete grafts. In recipients of T-cell-replete grafts, the patient's CMV-specific T-cell response was completely ablated. Because primary anti-CMV responses were rare during the first year, immunity depended essentially on the transfer of donor CMV-specific T cells and, therefore, on the CMV positivity of the donor. In the recipients of T-cell-depleted grafts, CMV-specific cytotoxic T cells were of recipient origin in 2 patients who underwent transplantation with CMV-negative donors and in 3 of 8 patients who underwent transplantation with CMV-positive donors, and they were of mixed or donor origin in the other 5 patients studied. Recipient CMV-specific T cells responded vigorously to antigen ex vivo and persisted for several years without replenishment by donor cells. Furthermore, they appeared to have a protective effect because CMV-related complications were absent in the patients with CMV-specific T cells of recipient origin. Clinical outcomes of a cohort of 91 patients corroborated the experimental results. Patients with recipient T cells in their blood were protected regardless of the donor immune status. Hence, when a T-cell depletion protocol is used that favors the survival of recipient T cells, the patient's pretransplantation CMV-specific immunity protects against posttransplantation CMV-related complications.
Databáze: OpenAIRE
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