N-Alkylated Sulfamic Acid Derivatives as Organocatalyst in Multicomponent Synthesis of Fatty Dihydropyrimidinones

Autor: Luiz Antonio de Almeida Pinto, Andressa C. H. Weber, Caroline Da Ros Montes D’Oca, Marcelo Gonçalves Montes D'Oca, Jaqueline Motta de Moura, Carolina R. L. Hack, Dennis Russowsky, Larissa M. Porciuncula
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of the Brazilian Chemical Society v.29 n.11 2018
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 29, Issue: 11, Pages: 2342-2349, Published: NOV 2018
Popis: In this work, N-alkylated sulfamic acid derivatives are introduced as promising acidic organocatalysts with convenient acidity and easy synthesis. The new organocatalysts derived from different nitrogenated compounds (amines, chitosan, urea and thiourea) were applied in multicomponent reactions to synthesize several dihydropyrimidinones (DHPMs). All tested organocatalysts resulted in good DHPM yields, using classic 1,3-dicarbonyl compounds and long-chain 1,3-dicarbonyl derivatives, demonstrating catalytic efficiency. N-Alkylated sulfamic acid derived from benzylamine showed good results (ca. 80% yields). In addition, excellent results were obtained with organocatalysts based on sulfamic acid and thiourea (ca. 80-97% yields), demonstrating the catalytic efficiency of new derivatives of thiourea organosulfamic catalysts.
Databáze: OpenAIRE