Usefulness of the delta neutrophil index as an ancillary test in the emergency department for the early diagnosis of suspected acute promyelocytic leukemia

Autor:	Ji Eun Jang, Jung Hwa Hong, Dong Ryul Ko, Je Sung You, Incheol Park, Jong Wook Lee, Taeyoung Kong, Sung Phil Chung, Hye Sun Lee
Rok vydání:	2017
Předmět:	Acute promyelocytic leukemia Cancer Research medicine.medical_specialty Neutrophils Antineoplastic Agents Tretinoin 030204 cardiovascular system & hematology Logistic regression Ancillary test 03 medical and health sciences 0302 clinical medicine Leukemia Promyelocytic Acute immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans In patient neoplasms Early Detection of Cancer Retrospective Studies Univariate analysis Immature Granulocyte business.industry Myeloid leukemia Hematology Emergency department medicine.disease Logistic Models Oncology 030220 oncology & carcinogenesis Immunology Emergency Service Hospital business
Zdroj:	Leukemia & Lymphoma. 58:2387-2394
ISSN:	1029-2403 1042-8194
Popis:	The delta neutrophil index (DNI) reflects the fraction of circulating immature granulocytes. We evaluated the usefulness of DNI values in patients with acute myeloid leukemia (AML) to distinguish the acute stage of acute promyelocytic leukemia (APL). We analyzed patients retrospectively who were first diagnosed with AML upon admission to the emergency department (ED). Thirty of the 134 patients (22.4%) were diagnosed with APL on ED admission. The univariate analysis and multivariate logistic regression models revealed that DNI values differed significantly between APL and non-APL AML patients on days 0, 1 and 2. Increased predictability for APL was associated with a DNI greater than 24.2% on ED admission, greater than 23.6% on day 1 and greater than 44% on day 2 in patients with AML. DNI values of patients with AML could discriminate the acute stage of APL from AML for immediate initiation of all-trans retinoic acid therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a70e4db34b30aace47102a779cd201 https://doi.org/10.1080/10428194.2017.1296142 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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