Long non‐coding RNA T‐cell factor 7 in multiple myeloma: A potential biomarker for deteriorated clinical features and poor prognosis

Autor: Liting Wu, Zhumeng Li, Wenfang Zhuang, Min Chu, Cui Zhang, Yingchao Fan, Xiaoyan Ma
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Clinical Biochemistry
clinical response
Gastroenterology
Dexamethasone
Bortezomib
chemistry.chemical_compound
0302 clinical medicine
Antineoplastic Combined Chemotherapy Protocols
T Cell Transcription Factor 1
Immunology and Allergy
Stage (cooking)
Multiple myeloma
Research Articles
biology
progressive‐free survival
Hematology
Middle Aged
Prognosis
multiple myeloma
Gene Expression Regulation
Neoplastic
Survival Rate
Medical Laboratory Technology
medicine.anatomical_structure
Real-time polymerase chain reaction
030220 oncology & carcinogenesis
Female
RNA
Long Noncoding
Antibody
Research Article
Microbiology (medical)
medicine.medical_specialty
T cell
overall survival
03 medical and health sciences
Lactate dehydrogenase
Internal medicine
medicine
Biomarkers
Tumor
Humans
Cyclophosphamide
Creatinine
business.industry
Biochemistry (medical)
Public Health
Environmental and Occupational Health
medicine.disease
long non‐coding RNA TCF7
030104 developmental biology
chemistry
Case-Control Studies
biology.protein
Bone marrow
business
Follow-Up Studies
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
Popis: Background This study aimed to investigate the correlation of long non‐coding RNA T‐cell factor 7 (lnc‐TCF7) with clinical features and prognosis in patients with multiple myeloma (MM). Methods Totally, 216 newly diagnosed symptomatic MM patients and 60 healthy controls (HCs) were enrolled. Bone marrow samples were collected from patients before treatment and from HCs on donation to detect lnc‐TCF7 expression in plasma cells by reverse transcription quantitative polymerase chain reaction. Besides, clinical response, progression‐free survival (PFS), and overall survival (OS) of patients were assessed. Results Lnc‐TCF7 expression was increased in patients with MM compared with HCs. Lnc‐TCF7 expression was highest in international staging system (ISS) stage III patients, followed by ISS stage II patients, and then ISS stage I patients, while lnc‐TCF7 expression was similar in patients with different immunoglobulin subtypes and Durie‐Salmon stages. Regarding chromosomal abnormalities, lnc‐TCF7 expression positively correlated with t(4; 14) and Del(17p), whereas no correlation of lnc‐TCF7 expression with t(14; 16), 1q21 amplification, Del(13q), or hyperdiploid was observed in patients with MM. Furthermore, lnc‐TCF7 expression positively correlated with serum creatinine, beta‐2‐microglobulin, and lactate dehydrogenase in patients. Besides, lnc‐TCF7 was negatively associated with complete response but not overall response rate in patients. Additionally, patients with lnc‐TCF7 high expression exhibited shorter PFS and OS compared to patients with lnc‐TCF7 low expression. Conclusion Lnc‐TCF7 might have clinical value in aiding disease management and prognosis prediction of MM.
Databáze: OpenAIRE
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