Parathyroid cell surface autoantibodies that inhibit parathyroid hormone secretion from dispersed human parathyroid cells
| Autor: | James T. Posillico, Lawrence E. Mallette, S. Srikanta, Edward M. Brown, George S. Eisenbarth, Jacobo Wortsman |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Hypoparathyroidism Endocrinology Diabetes and Metabolism Fluorescent Antibody Technique Parathyroid hormone Parathyroid Glands Antigen Internal medicine medicine Humans Orthopedics and Sports Medicine Secretion Aged Autoantibodies business.industry Autoantibody Parathyroid chief cell Middle Aged Flow Cytometry medicine.disease Endocrinology Parathyroid Hormone Antigens Surface Parathyroid hormone secretion Calcium Female Calcium-sensing receptor business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Bone and Mineral Research. 1:475-483 |
| ISSN: | 0884-0431 |
| Popis: | Serum autoantibodies directed toward antigenic determinants on the surface of human parathyroid cells (PTAb-CS) have been demonstrated in a subset (8 of 23) of adult patients with idiopathic hypoparathyroidism (IHP). In sera from 3 of 8 patients with PTAb-CS, binding of these autoantibodies to their respective parathyroid cell surface antigen(s) resulted in marked inhibition of parathyroid hormone (PTH) secretion in an in vitro dispersed human parathyroid cell (dPTC) system. In 1 subject evaluated longitudinally, circulating levels of PTAb-CS, and the magnitude of the inhibitory effect on PTH secretion, temporally correlated with the clinical course of the hypoparathyroidism. These findings suggest a causative role for antibodies directed against cell surface antigens in parathyroid dysfunction in some cases of "autoimmune" hypoparathyroidism. |
| Databáze: | OpenAIRE |
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