Prognostic impact of malignant diseases in idiopathic pulmonary fibrosis

Autor:	Jaeyoung Cho, Young Sik Park, Jinwoo Lee, Sang Min Lee, Chul Gyu Yoo, Nakwon Kwak, Hong Yeul Lee, Chang Hoon Lee, Sun Mi Choi, Young Whan Kim
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty Lung Neoplasms Databases Factual lcsh:Medicine Diseases Gastroenterology Article 03 medical and health sciences Idiopathic pulmonary fibrosis 0302 clinical medicine Medical research Risk Factors Internal medicine Neoplasms medicine Humans Lung cancer lcsh:Science Survival rate Aged Retrospective Studies Multidisciplinary Lung business.industry Hazard ratio lcsh:R Cancer Retrospective cohort study Middle Aged respiratory system medicine.disease Prognosis Confidence interval Idiopathic Pulmonary Fibrosis humanities respiratory tract diseases Survival Rate medicine.anatomical_structure 030228 respiratory system Oncology 030220 oncology & carcinogenesis Disease Progression Female lcsh:Q business Tomography X-Ray Computed
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports
ISSN:	2045-2322
Popis:	No studies on idiopathic pulmonary fibrosis (IPF) have investigated the prognostic impact of extrapulmonary cancers in patients with IPF. We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF between 2001 and 2015. Patients were divided into three groups: IPF without cancer (n = 440), IPF with lung cancer (n = 69), and IPF with extrapulmonary cancer (n = 70). Of the 579 patients with IPF, 139 (24%) had cancer; the three most common types were lung (11.9%), gastric (2.4%), and colorectal (1.9%). Survival was significantly worse in patients with lung cancer than in those without cancer (hazard ratio [HR] = 1.83, 95% confidence interval [CI], 1.35–2.48) or those with extrapulmonary cancer (HR = 1.70, 95% CI, 1.14–2.54). The rate of hospitalisation for cancer-related complications was significantly higher in IPF patients with lung cancer than in those with extrapulmonary cancer. The annual rates of decline in percent predicted forced vital capacity and diffusion capacity for carbon monoxide did not differ among the groups. Physicians should pay attention to the development and progression of cancer and its prognostic impact in patients with IPF.
Databáze:	OpenAIRE
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