Bicarbonate-responsive 'soluble' adenylyl cyclase defines a nuclear cAMP microdomain

Autor:	Jochen Buck, Kenneth C. Hess, Jeanne Farrell, David R Huron, Margarita Kamenetsky, Jonathan H. Zippin, Lonny R. Levin, Donald A. Fischman
Rok vydání:	2004
Předmět:	Gs alpha subunit Biology CREB Second Messenger Systems Article ADCY10 Cell Line Adenylyl cyclase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chlorocebus aethiops Cyclic AMP Animals Humans PKA gene expression compartmentalization signal transduction Phosphorylation Cyclic AMP Response Element-Binding Protein Protein kinase A education 030304 developmental biology Cell Nucleus 0303 health sciences education.field_of_study Cell Biology Soluble adenylyl cyclase Cyclic AMP-Dependent Protein Kinases Immunohistochemistry Rats Cell biology Enzyme Activation Bicarbonates Gene Expression Regulation chemistry Adenylyl Cyclase Inhibitors Hepatocytes biology.protein cAMP-dependent pathway CREB1 030217 neurology & neurosurgery Adenylyl Cyclases
Zdroj:	The Journal of Cell Biology
ISSN:	1540-8140 0021-9525
Popis:	Bicarbonate-responsive “soluble” adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a2ce2c05d290731f9b01b2d89068d1 https://doi.org/10.1083/jcb.200311119 Zobrazit plný text záznamu