Down syndrome associated moyamoya may worsen epilepsy control and can benefit from surgical revascularization
| Autor: | Sheila D. Smith, Sarah R. Garson, Stephen J. Monteith, Bart P. Keogh, Ryder P. Gwinn, Michael Doherty |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Down syndrome Bypass Cerebral arteries Article lcsh:RC321-571 030218 nuclear medicine & medical imaging 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Quality of life medicine.artery Internal medicine medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Stenosis business.industry medicine.disease Perfusion Neurology Middle cerebral artery Cardiology Wakefulness Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Epilepsy and Behavior Case Reports, Vol 11, Iss, Pp 14-17 (2019) Epilepsy & Behavior Case Reports |
| ISSN: | 2213-3232 |
| DOI: | 10.1016/j.ebcr.2018.09.008 |
| Popis: | Objectives To examine outcome of bilateral extracranial to intracranial (EC-IC) bypass surgeries for a Down syndrome patient with hard-to-treat epilepsy and moyamoya. Materials and methods Superficial temporal arteries were anastamosed using an indirect bypass technique to middle cerebral arteries bilaterally to help limit perfusion deficits and seizure controls. Results Two superficial temporal to middle cerebral artery indirect bypass surgeries were performed within 3 months. Post-revascularization improvements included seizure control, gait, perfusion, wakefulness, language and quality of life. Conclusion In patients with Down syndrome and moyamoya, improvements in seizure control and quality of life may occur with EC-IC bypass procedures. Highlights • Moyamoya blood flow compromises can be seen in Down syndrome. • Both moyamoya and Down syndrome are associated with Epilepsy. • If moyamoya related perfusion worsens, so can seizure control. • We report bilateral indirect extracranial to intracranial bypass surgeries in a Down syndrome patient with moyamoya. • The surgeries markedly improved seizure control and quality of life. |
| Databáze: | OpenAIRE |
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