Metabolism of Papaverine I. Identification of Metabolites in Rat Bile
| Autor: | Frans M. Belpaire, M. T. Rosseel, Bogaert Mg, Anteunis M |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
Chromatography Gas Magnetic Resonance Spectroscopy Chemical Phenomena Health Toxicology and Mutagenesis Pharmacology Tritium Toxicology Biochemistry Mass Spectrometry Hydrolysis Papaverine medicine Animals Bile Biotransformation Chemistry General Medicine Metabolism Rats Injections Intravenous Cats Chromatography Thin Layer Injections Intraperitoneal medicine.drug |
| Zdroj: | Xenobiotica. 5:413-420 |
| ISSN: | 1366-5928 0049-8254 |
| Popis: | 1. After hydrolysis with glusulase of bile from rats treated with papaverine, four metabolites (A, B, C and D) were separated.2. The structures of A, B and C were established as the monodemethylated compounds, 4′-desmethyl-, 7-desmethyl-, and 6-desmethylpapaverine, respectively.3. D was formed from papaverine by bis-demethylation. Since it was found in cat bile after administering either A or C, but not B, it was identified as 4′,6-desmethylpapaverine. |
| Databáze: | OpenAIRE |
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