Obsah

Magnetic Resonance Imaging of the Neuroprotective Effect of Xaliproden in Rats

Autor: Laurent Lemaire, Peter Keane, Jacqueline Fournier, Jean Vion-Dury, Sylviane Confort-Gouny, Yann Le Fur, Christian Ponthus, Patrick J. Cozzone
Přispěvatelé: Micro et Nanomédecines Translationnelles (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2002
Předmět:
Male
Time Factors
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Pyridines
MESH: Rats
Sprague-Dawley

MESH: Magnetic Resonance Imaging
Rats
Sprague-Dawley

chemistry.chemical_compound
0302 clinical medicine
Hippocampus (mythology)
MESH: Animals
Enzyme Inhibitors
MESH: Choline O-Acetyltransferase
0303 health sciences
medicine.diagnostic_test
Brain
MESH: Naphthalenes
MESH: Neuroprotective Agents
General Medicine
Magnetic Resonance Imaging
Vincristine Injection
Neuroprotective Agents
MESH: Enzyme Inhibitors
Vincristine
Anesthesia
medicine.drug
MESH: Rats
MESH: Vincristine
Naphthalenes
Neuroprotection
Choline O-Acetyltransferase
MESH: Brain
03 medical and health sciences
[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication
Alzheimer Disease
medicine
Animals
Radiology
Nuclear Medicine and imaging

Xaliproden
030304 developmental biology
business.industry
MESH: Pyridines
MESH: Time Factors
Magnetic resonance imaging
Rat brain
Mr imaging
MESH: Male
Rats
Disease Models
Animal

chemistry
MESH: Disease Models
Animal

business
MESH: Alzheimer Disease
030217 neurology & neurosurgery
Zdroj: Investigative Radiology
Investigative Radiology, Lippincott, Williams & Wilkins, 2002, 37 (6), pp.321-327. ⟨10.1097/00004424-200206000-00003⟩
Investigative Radiology, 2002, 37 (6), pp.321-327. ⟨10.1097/00004424-200206000-00003⟩
ISSN: 0020-9996
DOI: 10.1097/00004424-200206000-00003
Popis: RATIONALE AND OBJECTIVES. The neurotrophic effect of Xaliproden has been followed using sequential cerebral magnetic resonance imaging (MRI) in rats with vincristine-induced brain lesion as a model of Alzheimer disease. METHODS. Nineteen rats received an intraseptal injection of vincristine on day 0, followed by a daily gavage with either the vehicle (Tween-20 1%) (n = 10) or Xaliproden (10 mg/kg) (n = 9). Eight sham-operated controls received a daily gavage with either the vehicle (n = 4) or Xaliproden (n = 4). Brain MR imaging was performed at 4.7 T on a Biospec 47/30 MR system before surgery then 3, 7, 10, and 14 days after surgery. RESULTS. At day 3 following vincristine injection, an increase in MR signal intensity in the septum was observed on T2-weighted images. This increase was maximal at day 10, and remained stable until day 14. Daily treatment with Xaliproden delayed the appearance of hypersignals until day 7 and reduced by Ca. 50% the magnitude of the increase in signal intensity from day 10. No changes were observed in the hippocampus. CONCLUSION. Quantitative MRI objectifies noninvasively the neuroprotective effect of Xaliproden on rat brain anatomy.
Databáze: OpenAIRE
Pro tento záznam nejsou dostupné žádné jednotky.