Inositol lipid-mediated intranuclear signalling: a comparative analysis of in vivo labelling in interferon alpha-sensitive and -resistant Daudi lymphoma cells
| Autor: | R. Lisio, Sebastiano Miscia, Amelia Cataldi, Rosa Alba Rana, Iole Robuffo, Roberto Di Primio, Domenico Bosco |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Phosphatidylinositol 4 5-Diphosphate Adolescent Nuclear Envelope medicine.medical_treatment Drug Resistance Alpha interferon Down-Regulation Biology Phosphatidylinositols Second Messenger Systems Diglycerides chemistry.chemical_compound Membrane Lipids immune system diseases Interferon hemic and lymphatic diseases medicine Tumor Cells Cultured Humans Inositol Phosphorylation Diacylglycerol kinase Cell Nucleus B-Lymphocytes Lipid metabolism Cell Biology Molecular biology Burkitt Lymphoma Recombinant Proteins Cytokine chemistry Biochemistry Cell culture Interferon Type I lipids (amino acids peptides and proteins) Clone (B-cell biology) medicine.drug |
| Zdroj: | Cellular signalling. 5(3) |
| ISSN: | 0898-6568 |
| Popis: | Changes in inositol lipid and diacylglycerol metabolism have been analysed in Daudi lymphoma cells treated up to 24 h with human Dna recombinant interferon alpha. Results showing a different response of nuclear phosphoinositides and diacylglycerol, compared to whole cells, suggest that the intranuclear signalling system activated by interferon in Daudi cells involves nuclear inositol lipid metabolism. A well-characterized clone of Daudi cells selected for resistence to the antiproliferative action of interferon provided controls for the specificity of results. |
| Databáze: | OpenAIRE |
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