Measurement of myelin basic protein by radioimmunoassay in closed head trauma, multiple sclerosis and other neurological diseases
| Autor: | Amal Mukherjee, Robert F. Vogt, D. Scott Linthicum |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Moderate to severe
Pathology medicine.medical_specialty Multiple Sclerosis Clinical Biochemistry Radioimmunoassay macromolecular substances Myelin Cerebrospinal fluid Antigen Craniocerebral Trauma Humans Medicine biology business.industry Multiple sclerosis Myelin Basic Protein General Medicine medicine.disease Myelin basic protein medicine.anatomical_structure nervous system Immunology biology.protein Nervous System Diseases Closed head trauma business |
| Zdroj: | Clinical Biochemistry. 18:304-307 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/s0009-9120(85)80037-0 |
| Popis: | A double antibody sequential radioimmunoassay for human myelin basic protein (MBP) has been developed. The assay utilizes a rabbit antibody to human MBP and purified rabbit MBP as the radiolabelled antigen. This assay was used to analyze cerebrospinal fluid (CSF) from 22 patients with severe head injury, 61 other cases of various neurological disorders, and 106 normal controls. The results showed that closed head trauma caused moderate to severe elevations in CSF MBP, and elevated CSF MBP was detectable in several diseases which involve CNS myelin. |
| Databáze: | OpenAIRE |
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