An increase in milk IgA correlates with both pIgR expression and IgA plasma cell accumulation in the lactating mammary gland of PRM/Alf mice
| Autor: | Patrice Martin, Henri Salmon, Nisrine Boumahrou, Sylvain Bellier, Claire Chevaleyre, Mustapha Berri |
|---|---|
| Přispěvatelé: | Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, CNIEL and APIS-GENE, Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), UR Infectiologie animale et Santé publique (UR IASP), Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
cIga cell
medicine.medical_specialty Chemokine mammary gland Plasma Cells Immunology Mammary gland Plasma cell Mice 03 medical and health sciences Mammary Glands Animal 0302 clinical medicine Immune system Cell Movement Pregnancy Lactation Internal medicine Addressin medicine Animals Immunology and Allergy Cells Cultured mouse 030304 developmental biology 0303 health sciences milk biology Cell adhesion molecule digestive oral and skin physiology ccl28 Receptors Polymeric Immunoglobulin Obstetrics and Gynecology Epithelial Cells adhesion molecule Immunoglobulin A Intestines Mice Inbred C57BL Endocrinology medicine.anatomical_structure Reproductive Medicine biology.protein CCL28 [SDV.IMM]Life Sciences [q-bio]/Immunology Female 030215 immunology |
| Zdroj: | Journal of Reproductive Immunology Journal of Reproductive Immunology, Elsevier, 2012, 96 (1-2), pp.25-33. ⟨10.1016/j.jri.2012.08.001⟩ |
| ISSN: | 0165-0378 |
| DOI: | 10.1016/j.jri.2012.08.001⟩ |
| Popis: | Chantier qualité GA; In mice, during late pregnancy and lactation, maternal precursors of IgA-containing cells (cIgA-cells) are primed in the gut and home to the mammary gland where they secrete IgA. In turn, the ensuing increase in milk IgA mediates immune protection of the newborn gastrointestinal tract. PRM/Alf is an inbred mouse strain which exhibits a substantial post-natal intestinal lengthening which develops throughout the neonatal suckling period, suggesting that the availability of cIg-A cells and the level of protective IgA in milk might also be increased. We confirmed that PRM/Alf milk contains higher amounts of IgA than C57BL/6J throughout lactation, concomitantly with an increase of pIgR on epithelial cells and a higher density of cIgA-cells in the PRM/Alf mammary gland. Furthermore, a search for variations in cellular and humoral factors implicated in regulating cIgA-cell migration towards the mammary gland, including the vascular addressins MAdCAM-1 (mucosal addressin cell adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) as well as the mucosal epithelial chemokine CCL28, did not reveal any quantitative differences in expression between PRM/Alf and C57BL/6J mice strains. Thus our results indicate that these factors are not limiting in the recruitment of cIgA-cells released from the elongated gut of PRM/Alf mice. In the context of intestinal lengthening, these findings strengthen the notion of an entero-mammary gland link, where the neonatal gut is protected by the maternal gut through the immune function of the mammary gland. |
| Databáze: | OpenAIRE |
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