Expression of BAFF and BAFF receptors in primary Sjögren’s syndrome patients with ectopic germinal center-like structures

Autor: F. J. Carrillo-Ballesteros, C. A. Palafox-Sánchez, R. A. Franco-Topete, J. F. Muñoz-Valle, G. Orozco-Barocio, G. E. Martínez-Bonilla, C. E. Gómez-López, M. Marín-Rosales, E. F. López-Villalobos, S. Luquin, A. Castañeda-Chávez, Edith Oregon-Romero
Rok vydání: 2020
Předmět:
Adult
Male
musculoskeletal diseases
0301 basic medicine
medicine.medical_specialty
Transmembrane Activator and CAML Interactor Protein
medicine.medical_treatment
Salivary Glands
Minor
Severity of Illness Index
General Biochemistry
Genetics and Molecular Biology
Immunophenotyping
Pathogenesis
03 medical and health sciences
0302 clinical medicine
stomatognathic system
Internal medicine
B-Cell Activating Factor
medicine
Humans
B-Cell Maturation Antigen
skin and connective tissue diseases
B-cell activating factor
Receptor
Aged
Hematology
business.industry
Germinal center
General Medicine
Middle Aged
Germinal Center
medicine.disease
Sialadenitis
eye diseases
Pathophysiology
stomatognathic diseases
Sjogren's Syndrome
030104 developmental biology
Cytokine
Case-Control Studies
030220 oncology & carcinogenesis
Immunology
Female
business
B-Cell Activation Factor Receptor
Zdroj: Clinical and Experimental Medicine. 20:615-626
ISSN: 1591-9528
1591-8890
Popis: B cell-activating factor (BAFF) is an essential cytokine in primary Sjogren’s syndrome (pSS) physiopathology. It has been reported that pSS patients develop germinal center-like (GC-like) structures in their minor salivary glands (MSGs). BAFF, BAFF-R, TACI, and BCMA expression was analyzed in MSGs from 29 subjects (nonspecific chronic sialadenitis and focal lymphocytic sialadenitis with the presence [pSS-GC(+)] or absence [pSS-GC(−)] of GC-like structures). Twenty-four percent of patients showed ectopic GC-like structures and a high focus score [p
Databáze: OpenAIRE
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