Sublingual microcirculation in patients with SARS-CoV-2 undergoing veno-venous extracorporeal membrane oxygenation

Autor: Erika Casarotta, Claudia Scorcella, Simona Pantanetti, Roberto Carozza, Andrea Carsetti, Elisa Damiani, Francesco Gasparri, Vincenzo Gabbanelli, Erica Adrario, Jonathan Montomoli, Abele Donati, Roberta Domizi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Sublingual microcirculation
medicine.medical_specialty
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
medicine.medical_treatment
Pneumonia
Viral

Hemodynamics
030204 cardiovascular system & hematology
Biochemistry
Article
Microcirculation
Veins
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
Betacoronavirus
0302 clinical medicine
Refractory
Internal medicine
Extracorporeal membrane oxygenation
Medicine
Humans
In patient
Mouth Floor
Pandemics
Retrospective Studies
Microscopy
Video

business.industry
SARS-CoV-2
COVID-19
Cell Biology
Middle Aged
extracorporeal membrane oxygenation
Capillaries
030104 developmental biology
Breathing
Cardiology
Female
Endothelium
Vascular

business
Coronavirus Infections
Cardiology and Cardiovascular Medicine
Zdroj: Microvascular Research
ISSN: 0026-2862
DOI: 10.1016/j.mvr.2020.104064
Popis: Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) is a rescue treatment for severe acute respiratory failure refractory to conventional ventilation. We examined the alterations of sublingual microcirculation in patients with SARS-CoV-2 during VV-ECMO treatment and assessed the relationship between microvascular parameters and ventilation, hemodynamics, and laboratory tests. Nine patients were included in the study and the following microcirculatory parameters were estimated: TVD 16.81 (14.46-18.6) mm/mm2; PVD 15.3 (14.09-17.96) mm/mm2; PPV 94.85% (93.82%-97.79%); MFI 2.5 (2.5-2.92); HI 0.4 (0.18-0.4). TVD and PVD were inversely related to D-dimer levels (rho = -0.667, p = 0.05 and rho = -0.733, p = 0.025 respectively), aspartate aminotransferase (AST) (rho = -0.886, p = 0.019 and rho = -0.886, p = 0.019 respectively) and alanine aminotransferase (ALT) (rho = -0.829, p = 0.042 and rho = -0.829, p = 0.042 respectively). Our results showed an altered sublingual microcirculation in patients receiving VV-ECMO for severe SARS-CoV-2 and suggest a potential contribution of endothelia dysfunction to determine microvascular alteration.
Databáze: OpenAIRE
načítá se...