Sublingual microcirculation in patients with SARS-CoV-2 undergoing veno-venous extracorporeal membrane oxygenation
Autor: | Erika Casarotta, Claudia Scorcella, Simona Pantanetti, Roberto Carozza, Andrea Carsetti, Elisa Damiani, Francesco Gasparri, Vincenzo Gabbanelli, Erica Adrario, Jonathan Montomoli, Abele Donati, Roberta Domizi |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Sublingual microcirculation medicine.medical_specialty Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.medical_treatment Pneumonia Viral Hemodynamics 030204 cardiovascular system & hematology Biochemistry Article Microcirculation Veins Fibrin Fibrinogen Degradation Products 03 medical and health sciences Betacoronavirus 0302 clinical medicine Refractory Internal medicine Extracorporeal membrane oxygenation Medicine Humans In patient Mouth Floor Pandemics Retrospective Studies Microscopy Video business.industry SARS-CoV-2 COVID-19 Cell Biology Middle Aged extracorporeal membrane oxygenation Capillaries 030104 developmental biology Breathing Cardiology Female Endothelium Vascular business Coronavirus Infections Cardiology and Cardiovascular Medicine |
Zdroj: | Microvascular Research |
ISSN: | 0026-2862 |
DOI: | 10.1016/j.mvr.2020.104064 |
Popis: | Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) is a rescue treatment for severe acute respiratory failure refractory to conventional ventilation. We examined the alterations of sublingual microcirculation in patients with SARS-CoV-2 during VV-ECMO treatment and assessed the relationship between microvascular parameters and ventilation, hemodynamics, and laboratory tests. Nine patients were included in the study and the following microcirculatory parameters were estimated: TVD 16.81 (14.46-18.6) mm/mm2; PVD 15.3 (14.09-17.96) mm/mm2; PPV 94.85% (93.82%-97.79%); MFI 2.5 (2.5-2.92); HI 0.4 (0.18-0.4). TVD and PVD were inversely related to D-dimer levels (rho = -0.667, p = 0.05 and rho = -0.733, p = 0.025 respectively), aspartate aminotransferase (AST) (rho = -0.886, p = 0.019 and rho = -0.886, p = 0.019 respectively) and alanine aminotransferase (ALT) (rho = -0.829, p = 0.042 and rho = -0.829, p = 0.042 respectively). Our results showed an altered sublingual microcirculation in patients receiving VV-ECMO for severe SARS-CoV-2 and suggest a potential contribution of endothelia dysfunction to determine microvascular alteration. |
Databáze: | OpenAIRE |
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